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Cluster-Randomised Test Negative Designs: Inference and Application to Vector Trials to Eliminate Dengue

Series
Department of Statistics
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Nick Jewell, University of California, Berkeley School of Public Health, gives a talk for the departmental of Statistics on 28th May 2020.
Abstract: The successful introduction of the intracellular bacterium Wolbachia into Aedes aegypti mosquitoes enables a practical approach for dengue prevention through release of Wolbachia-infected mosquitoes. Wolbachia reduces dengue virus replication in the mosquito and, once established in the mosquito population, it is possible that this will provide a long-term and sustainable approach to reducing or eliminating dengue transmission. A critical next step is to assess the efficacy of Wolbachia deployments in reducing dengue virus transmission in the field. I will describe and discuss the statistical design of a large-scale cluster randomised test-negative parallel arm study to measure the efficacy of such interventions. Comparison of permutation inferential approaches to model based methods will be described. Extensions to allow for individual covariates, and alternate designs such as the stepped wedge approach, will also be briefly introduced. There are also interesting questions regarding interrupted time-series methods associated with analysing pilot site data.

Episode Information

Series
Department of Statistics
People
Nick Jewell
Keywords
statistics
dengue fever
Medicine
tropical diseases
mosquitoes
Department: Department of Statistics
Date Added: 10/06/2020
Duration: 01:02:53

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MCMC for Hierachical Bayesian Models Using Non-reversible Langevin Methods

Series
Department of Statistics
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Radford M. Neal (University of Toronto), gives a talk for the department of Statistics.
Hamiltonian Monte Carlo (HMC) is an attractive MCMC method for continuous distributions because it makes use of the gradient of the log probability density to propose points far from the current point, avoiding slow exploration by a random walk (RW). The Langevin method - equivalent to HMC with one leapfrog step - also uses gradient information, but is slow due to RW behaviour. In this talk, I discuss how the Langevin method can be made competitive with HMC using two modifications that suppress RW behaviour by making the Markov chain no longer be time-reversible. This modified Langevin method can be better than HMC when it is necessary to combine gradient-based updates with other updates. One use is when other updates are required for discrete variables. Another application is learning of hierarchical Bayesian neural networks models, for which hyperparameters controlling the properties of the function learned are difficult to update using HMC. If they are instead updated by, for example, Gibbs sampling, these updates can be done more often, improving sampling efficiency, when a non-reversible Langevin method is used rather than HMC with long trajectories.

Episode Information

Series
Department of Statistics
People
Radford M Neal
Keywords
statistics
Bayesian
MCMC
Langevin methods
hierarchical Bayesian
Department: Department of Statistics
Date Added: 10/06/2020
Duration: 01:04:36

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The role of the Today programme in a national crisis

Series
Reuters Institute for the Study of Journalism
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Sarah Sands, editor of the Today programme, on the role of the BBC flagship radio news show

Episode Information

Series
Reuters Institute for the Study of Journalism
People
Sarah Sands
Keywords
reuters institute
journalism
bbc
news
Department: Department of Politics and International Relations (DPIR)
Date Added: 09/06/2020
Duration: 00:57:08

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Fact checking a global story

Series
Reuters Institute for the Study of Journalism
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Clara Jiménez Cruz is co-founder and head of Maldita.es, a Spanish non-profit news organisation focused on stopping disinformation through fact-checking and data journalism

Episode Information

Series
Reuters Institute for the Study of Journalism
People
Clara Jiménez Cruz
Keywords
reuters institute
journalism
fact checking
Department: Department of Politics and International Relations (DPIR)
Date Added: 09/06/2020
Duration: 00:59:26

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What I learned by watching the American press try to cover Donald Trump

Series
Reuters Institute for the Study of Journalism
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Journalism lecturer and prominent media critic Jay Rosen outlines his thoughts on the US press's coverage of President Trump

Episode Information

Series
Reuters Institute for the Study of Journalism
People
Jay Rosen
Keywords
reuters institute
trump
journalism
Department: Department of Politics and International Relations (DPIR)
Date Added: 09/06/2020
Duration: 00:58:33

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Reporting pandemics: Measles and Coronavirus in the Pacific Islands

Series
Reuters Institute for the Study of Journalism
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Lagipoiva Cherelle Jackson, investigative reporter from Samoa speaks about reporting on the twin pandemics in the Pacific Islands

Episode Information

Series
Reuters Institute for the Study of Journalism
People
Lagipoiva Cherelle Jackson
Keywords
reuters institute
journalism
coronavirus
Department: Department of Politics and International Relations (DPIR)
Date Added: 09/06/2020
Duration: 00:55:32

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Buliding a global media brand

Series
Reuters Institute for the Study of Journalism
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Senior Editor at the Atlantic Prashant Rao discusses broadening the reach of the publication beyond the US

Episode Information

Series
Reuters Institute for the Study of Journalism
People
Prashant Rao
Keywords
reuters institute
journalism
Department: Department of Politics and International Relations (DPIR)
Date Added: 09/06/2020
Duration: 00:58:44

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Brexit in a time of crisis

Series
Reuters Institute for the Study of Journalism
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Anand Menon discusses whether the coronavirus pandemic has distracted attention from the Brexit negotiations

Episode Information

Series
Reuters Institute for the Study of Journalism
People
Anand Menon
Keywords
reuters institute
journalism
Brexit
Department: Department of Politics and International Relations (DPIR)
Date Added: 09/06/2020
Duration: 00:54:20

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Oxford Mathematics Public Lecture: Squirrels, Turing and Excitability - Mathematical Modelling in Biology, Ecology and Medicine

Series
The Secrets of Mathematics
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The Grey Squirrel invasion explaining tumour cell proliferation? Alan Turing explaining football shirt patterns? The close relationship between slugs and the human heart? What is the common link? Mathematics of course. And Philip Maini.
Oxford Mathematics Public Lectures are generously supported by XTX Markets.

Episode Information

Series
The Secrets of Mathematics
People
Philip Maini
Keywords
mathematics
Alan Turing
Department: Mathematical Institute
Date Added: 08/06/2020
Duration: 01:05:51

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Managing Stress and Overcoming Anxiety

Series
Our Mental Wellness
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Managing Stress and Overcoming Anxiety is the first talk in the Department of Experimental Psychology’s Our Mental Wellness Series. Associate Professor Jennifer Wild explores how certain people overcome enormous stress while others struggle.
And presents seven key tools to help us manage stress and anxiety in our own lives and the science of why they work. A Q and A Panel Discussion (chaired by Professor Catharine Creswell) follows with Professor Jennifer Wild, Emeritus Professor Robin Dunbar (evolutionary psychology) and Dr Polly Waite (adolescent clinical psychology).

Episode Information

Series
Our Mental Wellness
People
Jennifer Wild
Catharine Creswell
Robin Dunbar
Polly Waite
Keywords
mental health
Mental wellness
anxiety
stress
psychology
Worry
Department: Department of Experimental Psychology
Date Added: 08/06/2020
Duration: 00:40:28

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