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Cancer

Cancer is studied from several angles at NDM, from its epidemiology and potential causes, to its effect on patient lives and outcomes, as well as the basic science underpinning the unregulated cell growth that is the hallmark of the disease. Our Cancer podcasts illustrate the diversity of this research, and provide snapshots to the work of NDM scientists and clinicians to understand, treat and prevent cancer.

# Episode Title Description People Date
1 Creative Commons Epigenetic modifications and cancer Professor Skirmantas Kriaucionis aims to to elucidate the molecular function of DNA modifications in normal cells and cancer. Skirmantas Kriaucionis 14 Dec 2016
2 Repairing DNA damage Dr Ross Chapman studies the molecular events triggered by DNA damage detection, and why defects in these events lead to immune deficiency and cancer in humans. Ross Chapman 28 Apr 2016
3 Cleaning up misfolded proteins Misfolded proteins can either create the loss of a cellular function, or escape degradation, causing aggregation diseases. John Christianson 04 Feb 2016
4 Targeting cancer mechanisms Professor Robert Gilbert's research focuses on the molecular mechanisms underlying membrane pore formation and cell adhesion. Robert Gilbert 07 Jan 2016
5 Creative Commons Melanoma Melanoma or skin cancer is one of the fastest rising cancer types. When identified early, melanoma is relatively easy to cure, but once it starts to metastasise, it becomes very difficult to treat. Colin Goding 05 Oct 2015
6 Creative Commons Targeting epigenetics to treat cancer Transcription is a tightly regulated process, where chemical modifications initiate the duplication of genetic material. This epigenetic process is often dysregulated in cancer, but it can be targeted with small molecule inhibitors. Panagis Filippakopoulos 05 Oct 2015
7 Human Cancer Genetics Dr Gareth Bond, Associate Member of the Ludwig Institute for Cancer Research, studies the influence of genetic variants on the origins, progression and treatment of human cancer. Gareth Bond 11 Mar 2015
8 Personalised Medicine Dr Jenny Taylor is the Programme Director for the Genomic Medicine Theme, Wellcome Trust Centre for Human Genetics. Her research bridges the gap between genetics research and the use of its discoveries in diagnosis or treatment of medical conditions. Jenny Taylor 09 Feb 2015
9 Cancer predisposition and evolution Identifying genes that increase the risk of bowel or other cancers allows us to offer preventative measures, such as removing tumours at an early stage. A better understanding of how and why cancers grow also helps develop improved treatments. Ian Tomlinson 09 Feb 2015
10 Cancer Informatics Cancer research now generates huge amounts of data, and sophisticated computational tools are needed to answer biological questions. Making sense of this variability at molecular level will help us better tailor treatments to individual cancer patients. Benjamin Schuster-Böckler 09 Feb 2015
11 Stem cells and cancer Adult gastrointestinal stem cells Simon Leedham 10 Dec 2014
12 Cancer and innate immunity Inflammatory signalling Mads Gryd-Hansen 10 Dec 2014
13 Creative Commons Palliative Care Dr Bee Wee tells us about Palliative Care in Oxford and her research on end of life care and fatigue. Bee Wee 30 Aug 2011
14 Creative Commons Cancer and regenerative medicine Professor Xin Lu talks about the links between cancer and regenerative medicine. Xin Lu 22 Mar 2013
15 Creative Commons Cancer and Protein Crystallography Professor Yvonne Jones talks about cell-cell communication and how this can help us develop new drugs. Yvonne Jones 06 Jul 2011
16 Creative Commons Cancer Metabolism Dr Patrick Pollard tells us about his research on cancer metabolism. Patrick Pollard 10 Jul 2012
17 Creative Commons INDOX Cancer Research NetworK Dr Raghib Ali talks about INDOX, the cancer research network in India. Raghib Ali 09 Oct 2012
18 Creative Commons Renal Disease Professor Chris Pugh tells us about the links between genetics, renal disease and oxygen sensing. Chris Pugh 11 Oct 2011
19 Creative Commons Autophagy Dr Katja Simon tells us about her research on autophagy in red blood cells. Katja Simon 26 Apr 2011
20 Creative Commons Genome Integrity Dr Opher Gileadi tells us how cells maintain genome integrity and how we can use it in our fight against cancer. Opher Gileadi 01 Jun 2012
21 Creative Commons Role of Lifestyle and Diet in Cancer Professor Tim Key tells us about the role of life style and diet in the development of cancer. Tim Key 10 May 2011
22 Creative Commons Cancer Immunlogy Professor Vincenzo Cerundolo tells us how research in immunology leads to the development of new cancer treatments. Vincenzo Cerundolo 25 Mar 2013