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Nuffield Department of Clinical Medicine

The Nuffield Department of Medicine (NDM) is a large multi-disciplinary Department that links high quality basic biological science with medical application. Led by Professor Peter Ratcliffe FRS, who is both an active researcher in cell biology and an active clinician, the Department employs in the region of 1000 scientific research staff working in a range of basic science and clinical disciplines. Our researchers contribute to the teaching of 450 medical students within Oxford University's Clinical School.
Our base at the Headington Hospitals campus, Oxford, is now one of the largest centres for biomedical research in Europe with over £200M invested in capital projects and research infrastructure over the last decade. The rapidly growing campus provides a vibrant, highly interactive environment for research development. We are particularly committed to the career development of young scientists, including those from basic science as well as clinical backgrounds. In 2006 the Oxford University / Oxford Radcliffe Hospital Trust partnership successfully competed to be one of five UK Biomedical Research Centres. We played a leading role in this initiative, which provides a range of new opportunities for basic scientists to interact with clinical medical research, and for career development of clinician scientists.
In addition to its Oxford base, the Department operates a number of major overseas programmes in tropical medicine and global health, with research units in Thailand, Laos, Vietnam and Kenya supporting activities at numerous sites in S-E Asia and Sub-Saharan Africa. We also operate extensive epidemiological and clinical trials networks throughout China, India and South America.
In Oxford, NDM maintains research platforms across structural biology, protein biochemistry, genetics, genomics, proteomics, cell biology, chemical and genetic screening, imaging, bioinformatics, medical statistics, epidemiology, and clinical trials. Thematic research includes cancer biology, immunology, vaccinology, infectious diseases, gastroenterology, dermatology, diabetes and metabolic medicine, renal medicine, respiratory medicine, stroke medicine, and geratology.

Series associated with Nuffield Department of Clinical Medicine

Autoimmune Disease
Cancer
Career Equality Talks
Crossing Boundaries
Diabetes and Obesity
Epidemics and Vaccines
Genetics
Global Health
HIV
Immunology
Inspiring Women in Science
Malaria
McMichael Symposium
NDM International Activities
NDM Public Engagement
NDM Units
Nuffield Department of Medicine, Meet our Students
Revolutionary Biology
Translational and Clinical
Translational Medicine
Wellcome Trust Centre for Human Genetics
Women in Medical Science
# Episode Title Description People Date
1 Creative Commons Molecular diagnosis and bacterial genotyping Dr Janjira Thaipadungpanit from our MORU unit in Bangkok, Thailand, tells us about her research on molecular diagnosis and bacterial genotyping Janjira Thaipadungpanit 12 Apr 2017
2 Creative Commons Molecular diagnosis and bacterial genotyping Dr Janjira Thaipadungpanit from our MORU unit in Bangkok, Thailand, tells us about her research on molecular diagnosis and bacterial genotyping Janjira Thaipadungpanit 12 Apr 2017
3 Creative Commons Biomarkers for tropical diseases Dr Markus Winterbert from our MORU unit in Bangkok, Thailand, tells us about his research on biomarkers for tropical diseases Markus Winterberg 12 Apr 2017
4 Creative Commons Biomarkers for tropical diseases Dr Markus Winterbert from our MORU unit in Bangkok, Thailand, tells us about his research on biomarkers for tropical diseases Markus Winterberg 12 Apr 2017
5 Creative Commons MORU Biosafety Level 3 and melioidosis in Thailand Premjit Amornchai from our MORU unit in Bangkok, Thailand, tells us about her work as biosafety level 3 lab manager and microbioogy safety officer Premjit Amornchai 12 Apr 2017
6 Creative Commons MORU Biosafety Level 3 and melioidosis in Thailand Premjit Amornchai from our MORU unit in Bangkok, Thailand, tells us about her work as biosafety level 3 lab manager and microbioogy safety officer Premjit Amornchai 12 Apr 2017
7 Creative Commons Malaria control in Africa Professor Bob Snow from our KEMRI-Wellcome programme in Nairobi, Kenya, tells us how his research brings together epidemiological profiles and government policies to maximise malaria control programmes in Africa Bob Snow 12 Apr 2017
8 Creative Commons Malaria control in Africa Professor Bob Snow from our KEMRI-Wellcome programme in Nairobi, Kenya, tells us how his research brings together epidemiological profiles and government policies to maximise malaria control programmes in Africa Bob Snow 12 Apr 2017
9 Creative Commons Malaria elimination in the Greater Mekong sub-region Dr Lorenz von Seidlein from our MORU unit in Bangkok, Thailand, tells us about his research on malaria elimination in the Greater Mekong sub-region Lorenz von Seidlein 12 Apr 2017
10 Creative Commons Malaria elimination in the Greater Mekong sub-region Dr Lorenz von Seidlein from our MORU unit in Bangkok, Thailand, tells us about his research on malaria elimination in the Greater Mekong sub-region Lorenz von Seidlein 12 Apr 2017
11 Creative Commons Mapping bacterial antibiotic resistance Dr Olga Tosas-Auguet from our unit in Kenya tells us about her research on mapping bacterial antibiotic resistance Olga Tosas-Auguet 17 Feb 2017
12 Creative Commons Tracking infections Professor Derrick Crook from our Experimental Medicine division tells us about his research on tracking infections Derek Crook 10 Feb 2017
13 Creative Commons Bacterial infections in Laos David Dance from our LOMWRU unit in Laos tells us about his research on bacterial infections in Laos, particularly melioidosis David Dance 10 Feb 2017
14 Creative Commons Tracking infections Professor Derrick Crook from our Experimental Medicine division tells us about his research on tracking infections Derrick Crook 08 Feb 2017
15 Creative Commons Mapping bacterial antibiotic resistance Dr Olga Tosas-Auguet from our unit in Kenya tells us about her research on mapping bacterial antibiotic resistance Olga Tosas-Auguet 08 Feb 2017
16 Creative Commons Bacterial infections in Laos David Dance from our LOMWRU unit in Laos tells us about his research on bacterial infections in Laos, particularly melioidosis David Dance 08 Feb 2017
17 Creative Commons Optimising malaria treatment Dr Georgina Humphreys coordinates the WorldWide Antimalarial Resistance Network (WWARN) study groups by encouraging partner engagement and managing the data curation and development of publications. Georgina Humphreys 14 Dec 2016
18 Creative Commons Outbreak, the clinical research response Dr Gail Carson is Head of ISARIC Coordinating Centre (International Severe Acute Respiratory and Emerging Infection Consortium), a network of networks established in 2011 to ensure a rapid research response to outbreaks of pandemic potential. Gail Carson 14 Dec 2016
19 Creative Commons Epigenetic modifications and cancer Professor Skirmantas Kriaucionis aims to to elucidate the molecular function of DNA modifications in normal cells and cancer. Skirmantas Kriaucionis 14 Dec 2016
20 Creative Commons Fighting malaria in Myanmar Professor Frank Smithuis is the director of MOCRU, Myanmar Oxford Clinical Research Unit. MOCRU involves a network of 6 clinics and 650 community health workers in remote areas. Frank Smithuis 14 Dec 2016
21 Creative Commons Optimising malaria treatment Dr Georgina Humphreys coordinates the WorldWide Antimalarial Resistance Network (WWARN) study groups by encouraging partner engagement and managing the data curation and development of publications. Georgina Humphreys 14 Dec 2016
22 Creative Commons Outbreak, the clinical research response Dr Gail Carson is Head of ISARIC Coordinating Centre (International Severe Acute Respiratory and Emerging Infection Consortium), a network of networks established in 2011 to ensure a rapid research response to outbreaks of pandemic potential. Gail Carson 14 Dec 2016
23 Creative Commons Epigenetic modifications and cancer Professor Skirmantas Kriaucionis aims to to elucidate the molecular function of DNA modifications in normal cells and cancer. Skirmantas Kriaucionis 14 Dec 2016
24 Creative Commons Fighting malaria in Myanmar Professor Frank Smithuis is the director of MOCRU, Myanmar Oxford Clinical Research Unit. MOCRU involves a network of 6 clinics and 650 community health workers in remote areas. Frank Smithuis 14 Dec 2016
25 Why we work on Alzheimer’s disease Housed within the Target Discovery Institute, the Alzheimer’s Research UK Oxford Drug Discovery Institute (ODDI) juxtaposes drug discovery expertise alongside scientific and academic understanding of patients, disease mechanisms and model systems. John Davis 30 Nov 2016
26 Gastrointestinal cancers Dr Claire Palles studies whole genome sequencing data and targeted analyses with the aim of discovering genetic variants that affect susceptibility to colorectal cancer and Barrett’s oesophagus. Claire Palles 30 Nov 2016
27 Poor quality medicines LOMWRU researchers conduct clinical research to help improve global, regional and Lao public health. They focus on infectious diseases, and also investigate diseases of nutrition and poverty. Paul Newton 30 Nov 2016
28 Why we work on Alzheimer’s disease Housed within the Target Discovery Institute, the Alzheimer’s Research UK Oxford Drug Discovery Institute (ODDI) juxtaposes drug discovery expertise alongside scientific and academic understanding of patients, disease mechanisms and model systems. John Davis 30 Nov 2016
29 Gastrointestinal cancers Dr Claire Palles studies whole genome sequencing data and targeted analyses with the aim of discovering genetic variants that affect susceptibility to colorectal cancer and Barrett’s oesophagus. Claire Palles 30 Nov 2016
30 Poor quality medicines LOMWRU researchers conduct clinical research to help improve global, regional and Lao public health. They focus on infectious diseases, and also investigate diseases of nutrition and poverty. Paul Newton 30 Nov 2016
31 Creative Commons High altitude illness Director of OUCRU-Nepal, Dr Buddha Basnyat studies high altitude illness as well as undifferentiated febrile illness in the tropics, both common but neglected problems in Nepal. Buddha Basnyat 02 Nov 2016
32 Creative Commons High altitude illness Director of OUCRU-Nepal, Dr Buddha Basnyat studies high altitude illness as well as undifferentiated febrile illness in the tropics, both common but neglected problems in Nepal. Buddha Basnyat 02 Nov 2016
33 Creative Commons Infectious diseases in Indonesia Professor Kevin Baird leads our Eijkman-Oxford Clinical Research Unit (EOCRU) in Jakarta, Indonesia. Kevin Baird 02 Nov 2016
34 Creative Commons Finding the best malaria treatments Dr Mehul Dhorda heads the Asia Regional Centre of the WorldWide Antimalarial Resistance Network (WWARN). Mehul Dhorda 02 Nov 2016
35 Creative Commons Evolution and pathogenicity of viruses Professor Peter Simmonds studies the epidemiology, evolution and emergence of a wide range of human pathogenic viruses. Peter Simmonds 02 Nov 2016
36 Creative Commons Infectious diseases in Indonesia Professor Kevin Baird leads our Eijkman-Oxford Clinical Research Unit (EOCRU) in Jakarta, Indonesia. Kevin Baird 02 Nov 2016
37 Creative Commons Finding the best malaria treatments Dr Mehul Dhorda heads the Asia Regional Centre of the WorldWide Antimalarial Resistance Network (WWARN). Mehul Dhorda 02 Nov 2016
38 Creative Commons Evolution and pathogenicity of viruses Professor Peter Simmonds studies the epidemiology, evolution and emergence of a wide range of human pathogenic viruses. Peter Simmonds 02 Nov 2016
39 Creative Commons Introducing Mesh: The Global Health Network's Community Engagement Webspace This webinar features introductions from Francois Van Loggerenberg, scientific lead at the Global Health Network, and community engagement consultant Georgia Bladon to the community engagement platform Mesh. Francois van Loggerenberg, Georgia Blazon 31 Oct 2016
40 Creative Commons X-rays for drug discovery Professor Frank von Delft works to ensure that X-ray structures can serve as a routine and predictive tool for generating novel chemistry for targeting proteins. Frank von Delft 23 Sep 2016
41 Creative Commons X-rays for drug discovery Professor Frank von Delft works to ensure that X-ray structures can serve as a routine and predictive tool for generating novel chemistry for targeting proteins. Frank von Delft 23 Sep 2016
42 Method in the Motion A unique evening combining a scientific talk with inspirational dance. Irina Pulyakhina, Flux 14 Jul 2016
43 Creative Commons Modelling bacterial drug resistance Professor Ben Cooper from MORU in Thailand uses mathematical modelling and statistical techniques to help understand the dynamics of infectious disease and evaluate potential control measures. Ben Cooper 01 Jul 2016
44 Creative Commons Epidemiology and malaria elimination Dr Richard Maude's work combines clinical studies, descriptive epidemiology and mathematical modelling of malaria in South and Southeast Asia. Richard Maude 01 Jul 2016
45 Creative Commons Modelling bacterial drug resistance Professor Ben Cooper from MORU in Thailand uses mathematical modelling and statistical techniques to help understand the dynamics of infectious disease and evaluate potential control measures. Ben Cooper 01 Jul 2016
46 Creative Commons Epidemiology and malaria elimination Dr Richard Maude's work combines clinical studies, descriptive epidemiology and mathematical modelling of malaria in South and Southeast Asia. Richard Maude 01 Jul 2016
47 Creative Commons Why data management matters Naomi’s work focuses on supporting researchers to collect, clean and store research data. Naomi Waithira 02 Jun 2016
48 Malaria laboratory at MORU Dr Kesinee Chotivanich's laboratory provides facilities and resources to researchers, students, and collaborators who are interested in tropical diseases, with the aim to improve patients’ care. Kesinee Chotivanich 02 Jun 2016
49 Creative Commons From information to structure Dr Brian Marsden aims to make structural and chemical biology data accessible to non-experts, by providing computational resources including data management, sample tracking, in silico modelling support plus provision of public access to SGC data. Brian Marsden 02 Jun 2016
50 Why data management matters Naomi’s work focuses on supporting researchers to collect, clean and store research data. Naomi Waithira 02 Jun 2016
51 Malaria laboratory at MORU Dr Kesinee Chotivanich's laboratory provides facilities and resources to researchers, students, and collaborators who are interested in tropical diseases, with the aim to improve patients’ care. Kesinee Chotivanich 02 Jun 2016
52 Creative Commons From information to structure Dr Brian Marsden aims to make structural and chemical biology data accessible to non-experts, by providing computational resources including data management, sample tracking, in silico modelling support plus provision of public access to SGC data. Brian Marsden 02 Jun 2016
53 Repairing DNA damage Dr Ross Chapman studies the molecular events triggered by DNA damage detection, and why defects in these events lead to immune deficiency and cancer in humans. Ross Chapman 28 Apr 2016
54 Malaria in Kenya There is a great need for better treatments for malaria and for a preventative malaria vaccine. Philip Bejon 28 Apr 2016
55 Microbiology in the tropics The Cambodia Oxford Medical Research Unit (COMRU) is based in Siem Reap, northern Cambodia, which remains one of the poorest countries in South East Asia with extremely limited health services. Paul Turner 28 Apr 2016
56 Unravelling proteins Dr Nicola Burgess-Brown heads the Biotechnology Group at the SGC, which generates proteins suitable for structural and functional studies. Nicola Burgess-Brown 28 Apr 2016
57 Targeting drug discovery The development of new medicines is dependent on the identification of novel drug targets. Kilian Huber 28 Apr 2016
58 X-rays for drug discovery Dr Frank von Delft works to ensure that X-ray structures can serve as a routine and predictive tool for generating novel chemistry for targeting proteins. Frank von Delft 28 Apr 2016
59 Microbiology research in SE Asia Dr Direk Limmathurotsakul's research focuses on the epidemiology of melioidosis, a bacterial infection caused by Burkholderia pseudomallei. Direk Limmathurotsakul 28 Apr 2016
60 Tropical neonatology Dr Claudia Turner heads the clinical research program at the Cambodia Oxford Medical Research Unit (COMRU), in collaboration with the Angkor Hospital for Children. Claudia Turner 28 Apr 2016
61 Global health informatics Dr Chris Paton studies the use of open-source Electronic Health Records (EHR) software, online learning and mobile technology to improve healthcare delivery in low-resource settings. Chris Paton 28 Apr 2016
62 Dengue diagnosis and management With 390 million infections occuring each year, dengue is the most important mosquito-borne viral infection, and no vaccine is currently available. Bridget Wills 28 Apr 2016
63 Understanding growth signals Growth hormones and cytokines regulate the key physiological processes of growth and differentiation as well as responses to injury and infection. Alex Bullock 28 Apr 2016
64 Repairing DNA damage Dr Ross Chapman studies the molecular events triggered by DNA damage detection, and why defects in these events lead to immune deficiency and cancer in humans. Ross Chapman 28 Apr 2016
65 Malaria in Kenya There is a great need for better treatments for malaria and for a preventative malaria vaccine. Philip Bejon 28 Apr 2016
66 Microbiology in the tropics The Cambodia Oxford Medical Research Unit (COMRU) is based in Siem Reap, northern Cambodia, which remains one of the poorest countries in South East Asia with extremely limited health services. Paul Turner 28 Apr 2016
67 Unravelling proteins Dr Nicola Burgess-Brown heads the Biotechnology Group at the SGC, which generates proteins suitable for structural and functional studies. Nicola Burgess-Brown 28 Apr 2016
68 Targeting drug discovery The development of new medicines is dependent on the identification of novel drug targets. Kilian Huber 28 Apr 2016
69 X-rays for drug discovery Dr Frank von Delft works to ensure that X-ray structures can serve as a routine and predictive tool for generating novel chemistry for targeting proteins. Frank von Delft 28 Apr 2016
70 Microbiology research in SE Asia Dr Direk Limmathurotsakul's research focuses on the epidemiology of melioidosis, a bacterial infection caused by Burkholderia pseudomallei. Direk Limmathurotsakul 28 Apr 2016
71 Tropical neonatology Dr Claudia Turner heads the clinical research program at the Cambodia Oxford Medical Research Unit (COMRU), in collaboration with the Angkor Hospital for Children. Claudia Turner 27 Apr 2016
72 Global health informatics Dr Chris Paton studies the use of open-source Electronic Health Records (EHR) software, online learning and mobile technology to improve healthcare delivery in low-resource settings. Chris Paton 27 Apr 2016
73 Dengue diagnosis and management With 390 million infections occuring each year, dengue is the most important mosquito-borne viral infection, and no vaccine is currently available. Bridget Wills 27 Apr 2016
74 Understanding growth signals Growth hormones and cytokines regulate the key physiological processes of growth and differentiation as well as responses to injury and infection. Alex Bullock 27 Apr 2016
75 Variation across the human genome: a tricky balancing act in human health and disease Genetic variation can have opposing effects on human disease, where the benefits of a protective variant against one disease can increase the risk of another. Mary Carrington 10 Feb 2016
76 Malaria in pregnancy In pregnant women, severe malaria is responsible for high maternal mortality, and uncomplicated malaria results in in high morbidity. Rose McGready 04 Feb 2016
77 Reducing HIV Men who have sex with men (MSM) are a stigmatised group in Africa, but a predominant actor in the transmission of HIV. Eduard Sanders 04 Feb 2016
78 Cleaning up misfolded proteins Misfolded proteins can either create the loss of a cellular function, or escape degradation, causing aggregation diseases. John Christianson 04 Feb 2016
79 Rare neurological disorders Chorea-Acanthocytosis: ChAc is a rare progressive neurological disorder caused by mutations in a very complex gene. Antonio Velayos-Baeza 04 Feb 2016
80 Malaria in pregnancy In pregnant women, severe malaria is responsible for high maternal mortality, and uncomplicated malaria results in in high morbidity. Rose McGready 04 Feb 2016
81 Reducing HIV Men who have sex with men (MSM) are a stigmatised group in Africa, but a predominant actor in the transmission of HIV. Eduard Sanders 04 Feb 2016
82 Cleaning up misfolded proteins Misfolded proteins can either create the loss of a cellular function, or escape degradation, causing aggregation diseases. John Christianson 04 Feb 2016
83 Rare neurological disorders Chorea-Acanthocytosis: ChAc is a rare progressive neurological disorder caused by mutations in a very complex gene. Antonio Velayos-Baeza 04 Feb 2016
84 Targeting cancer mechanisms Professor Robert Gilbert's research focuses on the molecular mechanisms underlying membrane pore formation and cell adhesion. Robert Gilbert 07 Jan 2016
85 Inflammation in disease The main aim of Dr Xue's research is to understand the molecular and cellular mechanisms mediating inflammatory diseases, and to translate their findings into therapeutic concepts to treat these diseases. Luzheng Xue 07 Jan 2016
86 Computation and genetics Resistance to drugs in bacteria can be aquired by swapping genes between individual bacteria. Computer programs developed by Dr Iqbal enable doctors to predict which antibiotics will be met with drug resistance, enabling the selection of the right drug. Zamin Iqbal 07 Jan 2016
87 Targeting cancer mechanisms Professor Robert Gilbert's research focuses on the molecular mechanisms underlying membrane pore formation and cell adhesion. Robert Gilbert 07 Jan 2016
88 Inflammation in disease The main aim of Dr Xue's research is to understand the molecular and cellular mechanisms mediating inflammatory diseases, and to translate their findings into therapeutic concepts to treat these diseases. Luzheng Xue 07 Jan 2016
89 Computation and genetics Resistance to drugs in bacteria can be aquired by swapping genes between individual bacteria. Computer programs developed by Dr Iqbal enable doctors to predict which antibiotics will be met with drug resistance, enabling the selection of the right drug. Zamin Iqbal 07 Jan 2016
90 NDM Studentships Every year, about 60 DPhil students start a life changing experience in the Nuffield Department of Medicine at the University of Oxford. Robert Gilbert, Steinar Halldorsson, Sophie Andrews 02 Dec 2015
91 The Evolution of the Genome Computational and stastistical methods help us understand evolution as well as genetic disease. Gerton Lunter 02 Dec 2015
92 Tropical Immunology Melioidosis is a neglected tropical disease, and a major infectious killer in South East Asia. Melioidosis particularly affects people with diabetes. Susanna Dunachie 02 Dec 2015
93 Sharing data to fight malaria Over 250 Institutions participate in the effort of sharing data on the efficacy of antimalarial drugs, which involves standardising and re-analysing data. Philippe Guérin 02 Dec 2015
94 The Evolution of the Genome Computational and stastistical methods help us understand evolution as well as genetic disease. Gerton Lunter 02 Dec 2015
95 Tropical Immunology Melioidosis is a neglected tropical disease, and a major infectious killer in South East Asia. Melioidosis particularly affects people with diabetes. Susanna Dunachie 02 Dec 2015
96 Sharing data to fight malaria Over 250 Institutions participate in the effort of sharing data on the efficacy of antimalarial drugs, which involves standardising and re-analysing data. Philippe Guérin 02 Dec 2015
97 Science in a crisis, fast-forwarding clinical research for Ebola Professor Peter Horby's research focuses on epidemic diseases such as Ebola and bird flu, and crosses the disciplines of basic science, medical science and public health. Peter Horby 02 Dec 2015
98 Steinar Halldorsson Every year, about 60 DPhil students start a life changing experience in the Nuffield Department of Medicine in Oxford. Steinar Halldorsson 02 Dec 2015
99 Sophie Andrews Every year, about 60 DPhil students start a life changing experience in the Nuffield Department of Medicine in Oxford. Sophie Andrews 02 Dec 2015
100 Creative Commons The Heart and the Head, Part 5 Daniel Bulte, from the Department of Oncology, speaks about what happens when they discover an ‘incidental finding’. Daniel Bulte 16 Nov 2015