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Translational Medicine

Research in Medicine needs to ultimately translate into better treatment of patients. Researchers at the Nuffield Department of Medicine, University of Oxford, collaborate to develop better care and improved preventive measures. Findings in the laboratory are translated into changes in clinical practice, from Bench to Bedside.

# Episode Title Description People Date
1 Creative Commons Molecular diagnosis and bacterial genotyping Dr Janjira Thaipadungpanit from our MORU unit in Bangkok, Thailand, tells us about her research on molecular diagnosis and bacterial genotyping Janjira Thaipadungpanit 12 Apr 2017
2 Creative Commons Biomarkers for tropical diseases Dr Markus Winterbert from our MORU unit in Bangkok, Thailand, tells us about his research on biomarkers for tropical diseases Markus Winterberg 12 Apr 2017
3 Creative Commons MORU Biosafety Level 3 and melioidosis in Thailand Premjit Amornchai from our MORU unit in Bangkok, Thailand, tells us about her work as biosafety level 3 lab manager and microbioogy safety officer Premjit Amornchai 12 Apr 2017
4 Creative Commons Malaria control in Africa Professor Bob Snow from our KEMRI-Wellcome programme in Nairobi, Kenya, tells us how his research brings together epidemiological profiles and government policies to maximise malaria control programmes in Africa Bob Snow 12 Apr 2017
5 Creative Commons Malaria elimination in the Greater Mekong sub-region Dr Lorenz von Seidlein from our MORU unit in Bangkok, Thailand, tells us about his research on malaria elimination in the Greater Mekong sub-region Lorenz von Seidlein 12 Apr 2017
6 Creative Commons Tracking infections Professor Derrick Crook from our Experimental Medicine division tells us about his research on tracking infections Derek Crook 10 Feb 2017
7 Creative Commons Mapping bacterial antibiotic resistance Dr Olga Tosas-Auguet from our unit in Kenya tells us about her research on mapping bacterial antibiotic resistance Olga Tosas-Auguet 08 Feb 2017
8 Creative Commons Bacterial infections in Laos David Dance from our LOMWRU unit in Laos tells us about his research on bacterial infections in Laos, particularly melioidosis David Dance 08 Feb 2017
9 Creative Commons Optimising malaria treatment Dr Georgina Humphreys coordinates the WorldWide Antimalarial Resistance Network (WWARN) study groups by encouraging partner engagement and managing the data curation and development of publications. Georgina Humphreys 14 Dec 2016
10 Creative Commons Outbreak, the clinical research response Dr Gail Carson is Head of ISARIC Coordinating Centre (International Severe Acute Respiratory and Emerging Infection Consortium), a network of networks established in 2011 to ensure a rapid research response to outbreaks of pandemic potential. Gail Carson 14 Dec 2016
11 Creative Commons Epigenetic modifications and cancer Professor Skirmantas Kriaucionis aims to to elucidate the molecular function of DNA modifications in normal cells and cancer. Skirmantas Kriaucionis 14 Dec 2016
12 Creative Commons Fighting malaria in Myanmar Professor Frank Smithuis is the director of MOCRU, Myanmar Oxford Clinical Research Unit. MOCRU involves a network of 6 clinics and 650 community health workers in remote areas. Frank Smithuis 14 Dec 2016
13 Why we work on Alzheimer’s disease Housed within the Target Discovery Institute, the Alzheimer’s Research UK Oxford Drug Discovery Institute (ODDI) juxtaposes drug discovery expertise alongside scientific and academic understanding of patients, disease mechanisms and model systems. John Davis 30 Nov 2016
14 Gastrointestinal cancers Dr Claire Palles studies whole genome sequencing data and targeted analyses with the aim of discovering genetic variants that affect susceptibility to colorectal cancer and Barrett’s oesophagus. Claire Palles 30 Nov 2016
15 Poor quality medicines LOMWRU researchers conduct clinical research to help improve global, regional and Lao public health. They focus on infectious diseases, and also investigate diseases of nutrition and poverty. Paul Newton 30 Nov 2016
16 Creative Commons High altitude illness Director of OUCRU-Nepal, Dr Buddha Basnyat studies high altitude illness as well as undifferentiated febrile illness in the tropics, both common but neglected problems in Nepal. Buddha Basnyat 02 Nov 2016
17 Creative Commons Infectious diseases in Indonesia Professor Kevin Baird leads our Eijkman-Oxford Clinical Research Unit (EOCRU) in Jakarta, Indonesia. Kevin Baird 02 Nov 2016
18 Creative Commons Finding the best malaria treatments Dr Mehul Dhorda heads the Asia Regional Centre of the WorldWide Antimalarial Resistance Network (WWARN). Mehul Dhorda 02 Nov 2016
19 Creative Commons Evolution and pathogenicity of viruses Professor Peter Simmonds studies the epidemiology, evolution and emergence of a wide range of human pathogenic viruses. Peter Simmonds 02 Nov 2016
20 Creative Commons X-rays for drug discovery Professor Frank von Delft works to ensure that X-ray structures can serve as a routine and predictive tool for generating novel chemistry for targeting proteins. Frank von Delft 23 Sep 2016
21 Creative Commons Modelling bacterial drug resistance Professor Ben Cooper from MORU in Thailand uses mathematical modelling and statistical techniques to help understand the dynamics of infectious disease and evaluate potential control measures. Ben Cooper 01 Jul 2016
22 Creative Commons Epidemiology and malaria elimination Dr Richard Maude's work combines clinical studies, descriptive epidemiology and mathematical modelling of malaria in South and Southeast Asia. Richard Maude 01 Jul 2016
23 Creative Commons Why data management matters Naomi’s work focuses on supporting researchers to collect, clean and store research data. Naomi Waithira 02 Jun 2016
24 Malaria laboratory at MORU Dr Kesinee Chotivanich's laboratory provides facilities and resources to researchers, students, and collaborators who are interested in tropical diseases, with the aim to improve patients’ care. Kesinee Chotivanich 02 Jun 2016
25 Creative Commons From information to structure Dr Brian Marsden aims to make structural and chemical biology data accessible to non-experts, by providing computational resources including data management, sample tracking, in silico modelling support plus provision of public access to SGC data. Brian Marsden 02 Jun 2016
26 Repairing DNA damage Dr Ross Chapman studies the molecular events triggered by DNA damage detection, and why defects in these events lead to immune deficiency and cancer in humans. Ross Chapman 28 Apr 2016
27 Malaria in Kenya There is a great need for better treatments for malaria and for a preventative malaria vaccine. Philip Bejon 28 Apr 2016
28 Microbiology in the tropics The Cambodia Oxford Medical Research Unit (COMRU) is based in Siem Reap, northern Cambodia, which remains one of the poorest countries in South East Asia with extremely limited health services. Paul Turner 28 Apr 2016
29 Unravelling proteins Dr Nicola Burgess-Brown heads the Biotechnology Group at the SGC, which generates proteins suitable for structural and functional studies. Nicola Burgess-Brown 28 Apr 2016
30 Targeting drug discovery The development of new medicines is dependent on the identification of novel drug targets. Kilian Huber 28 Apr 2016
31 X-rays for drug discovery Dr Frank von Delft works to ensure that X-ray structures can serve as a routine and predictive tool for generating novel chemistry for targeting proteins. Frank von Delft 28 Apr 2016
32 Microbiology research in SE Asia Dr Direk Limmathurotsakul's research focuses on the epidemiology of melioidosis, a bacterial infection caused by Burkholderia pseudomallei. Direk Limmathurotsakul 28 Apr 2016
33 Tropical neonatology Dr Claudia Turner heads the clinical research program at the Cambodia Oxford Medical Research Unit (COMRU), in collaboration with the Angkor Hospital for Children. Claudia Turner 28 Apr 2016
34 Global health informatics Dr Chris Paton studies the use of open-source Electronic Health Records (EHR) software, online learning and mobile technology to improve healthcare delivery in low-resource settings. Chris Paton 28 Apr 2016
35 Dengue diagnosis and management With 390 million infections occuring each year, dengue is the most important mosquito-borne viral infection, and no vaccine is currently available. Bridget Wills 28 Apr 2016
36 Understanding growth signals Growth hormones and cytokines regulate the key physiological processes of growth and differentiation as well as responses to injury and infection. Alex Bullock 28 Apr 2016
37 Malaria in pregnancy In pregnant women, severe malaria is responsible for high maternal mortality, and uncomplicated malaria results in in high morbidity. Rose McGready 04 Feb 2016
38 Reducing HIV Men who have sex with men (MSM) are a stigmatised group in Africa, but a predominant actor in the transmission of HIV. Eduard Sanders 04 Feb 2016
39 Cleaning up misfolded proteins Misfolded proteins can either create the loss of a cellular function, or escape degradation, causing aggregation diseases. John Christianson 04 Feb 2016
40 Rare neurological disorders Chorea-Acanthocytosis: ChAc is a rare progressive neurological disorder caused by mutations in a very complex gene. Antonio Velayos-Baeza 04 Feb 2016
41 Targeting cancer mechanisms Professor Robert Gilbert's research focuses on the molecular mechanisms underlying membrane pore formation and cell adhesion. Robert Gilbert 07 Jan 2016
42 Inflammation in disease The main aim of Dr Xue's research is to understand the molecular and cellular mechanisms mediating inflammatory diseases, and to translate their findings into therapeutic concepts to treat these diseases. Luzheng Xue 07 Jan 2016
43 Computation and genetics Resistance to drugs in bacteria can be aquired by swapping genes between individual bacteria. Computer programs developed by Dr Iqbal enable doctors to predict which antibiotics will be met with drug resistance, enabling the selection of the right drug. Zamin Iqbal 07 Jan 2016
44 The Evolution of the Genome Computational and stastistical methods help us understand evolution as well as genetic disease. Gerton Lunter 02 Dec 2015
45 Tropical Immunology Melioidosis is a neglected tropical disease, and a major infectious killer in South East Asia. Melioidosis particularly affects people with diabetes. Susanna Dunachie 02 Dec 2015
46 Sharing data to fight malaria Over 250 Institutions participate in the effort of sharing data on the efficacy of antimalarial drugs, which involves standardising and re-analysing data. Philippe Guérin 02 Dec 2015
47 Creative Commons Artemisinin Resistance Artemisinins are very poweful tools in the treatment of malaria, and the emerging loss of their activity has the potential to create a major public health problem. Charlie Woodrow 05 Oct 2015
48 Creative Commons The ethics of research Identifying and addressing ethical issues are key to the success of any clinical trials, particularly when working with vulnerable populations. Phaik Yeong Cheah 05 Oct 2015
49 Creative Commons Science and Society In settings with high level of poverty and over-stretched health services, researchers have even greater responsibilities to the communities and study participants. Vicki Marsh 05 Oct 2015
50 Creative Commons Melanoma Melanoma or skin cancer is one of the fastest rising cancer types. When identified early, melanoma is relatively easy to cure, but once it starts to metastasise, it becomes very difficult to treat. Colin Goding 05 Oct 2015
51 Creative Commons Targeting epigenetics to treat cancer Transcription is a tightly regulated process, where chemical modifications initiate the duplication of genetic material. This epigenetic process is often dysregulated in cancer, but it can be targeted with small molecule inhibitors. Panagis Filippakopoulos 05 Oct 2015
52 Creative Commons A deep breath in Asthma and COPD (chronic obstructive pulmonary disease) are common conditions that affect the lives of many people. Mona Bafadhel 28 Jul 2015
53 Creative Commons Chemistry, epigenetics and drugs Alteration of gene expression is fundamental to many diseases. A better understanding of how epigenetic proteins affect diseases provides a starting point for therapy development and the discovery of new drug. Paul Brennan 28 Jul 2015
54 Creative Commons The genetics of metabolic diseases A missing step in a metabolic pathway leads to the build-up of toxic compounds, and the lack of materials essential for normal function. Wyatt Yue 28 Jul 2015
55 Creative Commons The economics of tropical diseases Economics and health are interlinked in many ways, as seen in the vicious cycle between poverty and ill health. Yoel Lubell 28 Jul 2015
56 Creative Commons Getting the dose right Too high a dose can result in toxicity and side-effects, too low a dose can cause the illness to come back and at worse develop resistance. Joel Tarning 28 Jul 2015
57 Enteric fever Dr Christiane Dolecek speaks about the research on enteric fever she conducted in Vietman and Nepal. Christiane Dolecek 20 May 2015
58 Emerging Infectious Diseases Professor Peter Horby is Senior Clinical Research Fellow. His research focusses on epidemic diseases such as Ebola and bird flu, and crosses the disciplines of basic science, medical science and public health. Peter Horby 11 Mar 2015
59 Human Cancer Genetics Dr Gareth Bond, Associate Member of the Ludwig Institute for Cancer Research, studies the influence of genetic variants on the origins, progression and treatment of human cancer. Gareth Bond 11 Mar 2015
60 Personalised Medicine Dr Jenny Taylor is the Programme Director for the Genomic Medicine Theme, Wellcome Trust Centre for Human Genetics. Her research bridges the gap between genetics research and the use of its discoveries in diagnosis or treatment of medical conditions. Jenny Taylor 09 Feb 2015
61 Cancer predisposition and evolution Identifying genes that increase the risk of bowel or other cancers allows us to offer preventative measures, such as removing tumours at an early stage. A better understanding of how and why cancers grow also helps develop improved treatments. Ian Tomlinson 09 Feb 2015
62 Cancer Informatics Cancer research now generates huge amounts of data, and sophisticated computational tools are needed to answer biological questions. Making sense of this variability at molecular level will help us better tailor treatments to individual cancer patients. Benjamin Schuster-Böckler 09 Feb 2015
63 Biological imaging Video microscopy aims to improve target discovery and drug development and to do so generates large volumes of data. Jens Rittscher 09 Feb 2015
64 Pharmacogenomics Dr Sebastian Nijman develops new approaches to study signalling networks in cancer cells and uncover specific weaknesses, particularly in breast and lung cancer. This can be used to develop more effective drugs and to better guide treatment decisions. Sebastian Nijman 09 Feb 2015
65 Creative Commons Microbiology in Thailand Microbiology in Thailand Stuart Blacksell 10 Dec 2014
66 Creative Commons Infectious diseases in South East Asia Infectious diseases in South East Asia Nick Day 10 Dec 2014
67 Creative Commons Rickettsial Disease Daniel Paris: Rickettsial Disease Daniel Paris 10 Dec 2014
68 Better hospitals for children Oxford Health Systems Research Collaboration (OHSCAR) Mike English 10 Dec 2014
69 Health systems research Governance in practice Sassy Molyneux 10 Dec 2014
70 Virus entry Novel light microscopy techniques allow us to track single viruses. Sergi Padilla-Parra 10 Dec 2014
71 DNA replication and Cancer DNA replication and Cancer Catherine Green 10 Dec 2014
72 Big Data Over the past decade, data-driven science has produced enormous sets of data. Christopher Yau 10 Dec 2014
73 Between research and humanitarian Between research and humanitarian Francois Nosten 10 Dec 2014
74 Creative Commons Tuberculous Meningitis Tuberculous Meningitis Guy Thwaites 07 Oct 2014
75 Creative Commons Crohn's disease Innate immune system Alison Simmons 07 Oct 2014
76 Structural biology and vaccines Structure of viruses Dave Stuart 07 Oct 2014
77 Creative Commons Stem cells and cancer Adult gastrointestinal stem cells Simon Leedham 07 Oct 2014
78 Creative Commons Cancer and innate immunity Inflammatory signalling Mads Gryd-Hansen 07 Oct 2014
79 Asthma Airway inflammation Ian Pavord 07 Oct 2014
80 Creative Commons Pneumococcal diseases Genetics and genomics of Streptococcus pneumoniae Angela Brueggemann 07 Oct 2014
81 Creative Commons Active and passive immunity to Influenza Professor Townsend tells us about lessons to be drawn from the history of immunology in Oxford, from 1979 onwards, until his current research on active and passive immunity to influenza. Alain Townsend 01 Oct 2013
82 Creative Commons Human Genetics Professor Peter Donnelly tells us how genetics helps us to understand common diseases and develop new drugs. Peter Donnelly 09 Jul 2013
83 Creative Commons The Global Health Network Dr Trudie Lang tells us how the Global Health Network facilitates collaboration and resource sharing. Trudie Lang 26 Jun 2013
84 Creative Commons Artemisinin therapy for malaria by Professor Nick White Professor Nick White talks about the future of artemisinin and other drug therapies for malaria. Nick White 18 Jun 2013
85 Creative Commons Atherosclerosis and immunity by Professor Chris O'Callaghan Professor Chris O'Callaghan tells us about the role of our immune system in vascular disease. Chris O’Callaghan 11 Jun 2013
86 Respiratory Medicine Dr Najib Rahman talks about his research on respiratory medicine. Najib Rahman 28 May 2013
87 Creative Commons Psychiatric genetics Professor Jonathan Flint talks about his research on psychiatric genetics. Jonathan Flint 21 May 2013
88 Creative Commons Development of chemical probes Professor Stefan Knapp tells us how the development of chemical probes helps us to find new drugs. Stefan Knapp 21 May 2013
89 Can we block malaria transmission Dr Sumi Biswas talks about the development of a vaccine aimed at the mosquito stage of the malaria parasite cycle. Sumi Biswas 07 May 2013
90 Creative Commons Membrane proteins and drug development Dr Liz Carpenter talks about her research on membrane proteins and drug development. Liz Carpenter 29 Apr 2013
91 Creative Commons MedicineAfrica Dr Alexander Finlayson tells us how MedicineAfrica aims to bring healthcare professionals around the world in a global expert network. Alexander Finlayson 29 Apr 2013
92 Creative Commons Structural cell biology of virus infection Professor Kay Grunewald tells us how structural cell biology can help us understand virus infection. Kay Grunewald 29 Apr 2013
93 Molecular immunology Dr Christian Eggeling tells us how new imaging methods help us understand immunology at the molecular level. Christian Eggeling 29 Apr 2013
94 Creative Commons The lymphatic system in immunity and cancer Professor David Jackson tells us about the role of the lymphatic system in immunity and cancer. David Jackson 29 Apr 2013
95 Cutaneous immunology Professor Graham Ogg talks about the role of our skin as a barrier against infection. Graham Ogg 29 Apr 2013
96 Creative Commons Fiona Powrie Professor Fiona Powrie talks about the importance of our guts, and her research in gastroenterology. Fiona Powrie 29 Apr 2013
97 Creative Commons Clinical Trials in Gastroenterology Dr Simon Travis tells us how clinical trials bring tomorrows treatments to patients today. Simon Travis 25 Mar 2013
98 Creative Commons Cancer Immunlogy Professor Vincenzo Cerundolo tells us how research in immunology leads to the development of new cancer treatments. Vincenzo Cerundolo 25 Mar 2013
99 Creative Commons Cancer and regenerative medicine Professor Xin Lu talks about the links between cancer and regenerative medicine. Xin Lu 22 Mar 2013
100 Creative Commons How the immune system detects flu virus Dr Jan Rehwinkel talks about the role of our innate immune system in our fight against flu virus. Jan Rehwinkel 22 Mar 2013