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Evidence-Based Medicine

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Misunderstandings and misuses of commonly-cited methods for systematic reviews & meta-analyses.

Professor Julian Higgins explains why he believes the systematic review and meta-analysis methods described in many highly cited papers are routinely misunderstood or misused.

Not just "what," but also "how well:" Intervention fidelity in clinical trials of complex interventions in healthcare

The concepts of intervention fidelity and how they can influence the results of clinical trials.

Stein's paradox

Dr Jason Oke, gives a talk on Stein's work, the paradox and some of its more controversial results and consider the implications for evidence-based medicine

Artificial Intelligence and Health Security, managing the risks

Professor Karl Roberts, University of New England, NSW, Australia gives a talk on generative AI and large language models as applied to healthcare.

Evidence-based dentistry: The building of the Dental Fact Box repository – OHA!

An introduction to OHA!, a tool currently being developed which aims to assist dentists in accessing the most reliable evidence regarding the effectiveness of common dental treatments.

Speedy or sloppy?: The opportunities and challenges of rapid qualitative research

Using a variety of examples of fast and slow qualitative research this talk explores the affordances of rapid methods, and help researchers decide if and where to use them in their own work.

Realist inquiry in global health practice: trials, tribulations (& triumphs?)

Dr Sara Van Belle, Institute of Tropical Medicine, Antwerp gives a talk on the practice of realist inquiry in global health.

Testing usability and impact of the OxRisk prediction models

Professor Seena Fazel, University of Oxford gives a talk on recent advances in prognostic modelling in psychiatry.

Alcohol and cardiovascular disease: Is moderate drinking really beneficial for cardiovascular disease?

Dr Derrick Bennett, University of Oxford gives a talk on the epidemiological evidence of alcohol and cardiovascular disease.

Professor Carl Heneghan

Georgina Ferry interviews Carl Heneghan, Professor of Evidence Based Medicine, 4 July 2022.

Sporadic, late-onset, and multi-stage diseases

Dr Anthony Webster, University of Oxford gives a talk on combining mathematical modelling with big data statistics to distinguish between sporadic, late-onset, and multi-stage diseases.

How do you carry out a realist synthesis of an intervention when there's 'no evidence'?

Joanne Greenhalgh, Professor of Applied Social Research Methodology (University of Leeds) on the experiences of conducting a realist synthesis of the feedback of aggregated patient reported outcome measure (PROMs) data to improve patient care.

Overdiagnosis and Lung Cancer Screening

Recent results of the NELSON Lung Cancer Screening Trial reports reductions in lung-cancer survival but not overall survival - The desire to detect disease even earlier means Overdiagnosis is on the rise.

When meta-analyses of the same question find different things

Dr Jamie Hartmann-Boyce discusses a case study of systematic reviews of electronic cigarettes for smoking cessation, looking across meta-analyses in this area.

Conflicts of Interest in Medicine: Why it’s time for a UK Sunshine Act

Should doctors with commercial interests lead research on their products? Should we forget ‘conflicts’ and discuss ‘declarations of interest’ instead? Who should hold and maintain conflicts of interest registers for doctors?

Realist research in practice - informing a new TB policy in Georgia

Professor Bruno Marchal gives a talk illustrating the principles of realist evaluation using the case of the development of a new Tuberculosis control policy in Georgia.

Evidence isn't enough: The politics and practicalities of communicating health research

The logic and principles behind the drive for evidence-based health care are so compelling that often the limitations of evidence go unacknowledged.

Operationalising the potential of Applied Digital Health research

The increased reliance of health systems on the digital record as the primary mechanism for storing data on consultations and other health interactions has opened new opportunities for research, healthcare innovation, and health policy.

Everything is a poison

Professor Jeffrey Aronson, Consultant Physician and Clinical Pharmacologist, Department of Primary Care Health Sciences, gives a talk on dose-response curves for the EBHC podcast series.

Safe and effective drugs: The need to use all the available evidence to inform the effectiveness of commonly used medicines

Carl Heneghan, Professor of Evidence-Based Medicine, employs evidence-based methods to research diagnostic reasoning, test accuracy and communicating diagnostic results to a wider audience.

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