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Professor Anna Petherick

Series
Collecting COVID: Oral Histories
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Georgina Ferry interviews Anna Petherick, Associate Professor in Public Policy, 20 December 2021.
Topics discussed include (00:00:30) AP's early studies in Natural Sciences at Cambridge including population modelling and evolutionary genetics, role as a journalist in San Francisco working at the Economist in South America, MPhil and DPhil in Comparative Government at Oxford with Tim Power as supervisor; (00:02:46) research and journalism and how these complement one another; (00:03:50) AP's key drive behind academic research; (00:05:30) AP's first memories of COVID-19; (00:07:30) project working with Thomas Hale at the Blavatnik School, seminar and meetings to discuss this new project; (00:10:22) Oxford COVID-19 Government Response Tracker; (00:13:20) the process involved, including using the coding manual; (00:15:44) research based upon the project; (00:17:30) research on behavioural and pandemic fatigue; (00:21:05) comparing countries for their different levels of trust in institutions and strangers; (00:23:56) funding for the project; (00:25:42) the collaborative nature of the research; (00:28:13) collaboration between institutions creating different datasets; (00:30:28) comparisons between countries or sub-state entities; (00:33:21) authoritarian countries and response to the pandemic; (00:35:12) economic ranking of countries and pandemic preparedness; (00:36:05) low and middle income countries that have performed well; (00:38:03) mitigator countries and eliminator countries; (00:40:04) direct influence on policy attributed to the project, including at the Cabinet Office; (00:41:11) the intensity of work during the pandemic; (00:43:00) consensus from the biomedical community; (00:47:49) recommendations and conclusions drawn from different policy approaches; (00:54:13) the need for a global exchange of data for climate change; (00:56:23) the personal impact of lockdown restrictions on work and research; (00:58:38) the level of support available for colleagues during the pandemic; (00:59:40) teaching both in-person and remotely with international students; (01:01:49) research questions of interest in the future; (01:02:25) future research interests, including the building back agenda; (01:05:03) opportunities afforded by this period for the empirical social sciences; (01:06:00) approach to work since the pandemic, including well-being, research practices and the credit system.

Episode Information

Series
Collecting COVID: Oral Histories
People
Anna Petherick
Georgina Ferry
Keywords
Social Sciences
government policy
covid-19 (disease)
Department: Bodleian Libraries
Date Added: 29/07/2022
Duration:

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Professor Peter Horby

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Collecting COVID: Oral Histories
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Georgina Ferry interviews Sir Peter Horby, Professor of Emerging Infectious Diseases, 6 December 2021.
Topics discussed include (00:00:45) PH's early training in medicine, interest in biology and infectious diseases; (00:02:38) PH's first job working on a HIV ward at Middlesex Hospital and later the Hospital for Tropical Diseases in London, work in Vietnam on SARS-1 in 2003 and in Hanoi for the World Health Organisation, work with Jeremy Farrar particularly with regards to opening the National Hospital of Tropical Diseases; (00:05:22) main threats for Vietnam, in terms of infectious disease outbreaks, work with Professor Liam, resurgence of H5N1 bird flu in 2003-4; (00:07:34) controls required to prevent transmission of prior infectious diseases, including SARS-1 and bird flu; (00:09:48) work in Singapore on infectious disease programme, return to the U.K. to Oxford in 2014 with the Epidemic Diseases Research Group, West Africa Ebola outbreak; (00:10:47) 2009 influenza pandemic; (00:12:57) International Severe Acute Respiratory and Emerging Infections Consortium [ISARIC], clinical trials and treatments for Ebola; (00:16:28) first awareness of COVID-19, ProMED report of 30 December 2019, preparedness to research an emerging infectious disease, collaboration with Chinese colleagues, focus on patients in research, the first clinical description and clinical trials set up in Wuhan, China; (00:22:00) clinical trials for MERS run by colleague Yaseen Arabi and adaptation of therapeutic trials for COVID-19 including starting randomised control trials in China with drug lopinavir/ritonavir, first placebo controlled trial, remdesivir antiviral trial in China in February (00:27:57) grant application to the Medical Research Council for research to expand the clinical trial research programme in China; (00:29:07) RECOVERY trial and collaboration with Martin Landray on this study; (00:35:15) data linkage and data collection, National Institute for Health Research [NIHR]; (00:36:38) meeting with Chris Whitty [Chief Medical Officer] and Jonathan Van-Tam [Deputy Chief Medical Officer] on 10 March 2020 to request sign-off for the trial; (00:40:00) particular drugs trialled to treat patients in hospital with COVID; (00:41:36) the impact of the trial results on treatment guidelines and policy with both effective and ineffective drugs, particularly with hydroxychloroquine [ineffective] and dexamethasone, tocilizumab and Ronapreve [effective]; (00:50:14) clinical characterisation database; (00:53:40) New and Emerging Respiratory Virus Threats Advisory Group [NERVTAG], SAGE, and policy-making at government level; (00:56:27) Pandemic Sciences Centre, Oxford, meeting with Richard Cornall (Head of the Nuffield Department of Clinical Medicine) in relation to the centre, coordination of science across the University and bringing together expertise; (01:02:10) impact of mitigating regulations for pandemic on working arrangements, including working from home; (01:03:30) PH's personal response to the threat of COVID-19; (01:04:53) personal well-being during lockdown and finding purpose in work; (01:07:05) future research interests, including the benefits of immunomodulation; (01:09:14) investment in global health research; (01:12:53) international organising in terms of emerging infectious diseases, particularly investment in people, infrastructure and reacting at speed.

Episode Information

Series
Collecting COVID: Oral Histories
People
Peter Horby
Georgina Ferry
Keywords
medical sciences
communicable diseases
Epidemiology
clinical trials
covid-19 (disease)
Department: Bodleian Libraries
Date Added: 29/07/2022
Duration: 01:13:38

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Professor Erica Charters

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Collecting COVID: Oral Histories
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Georgina Ferry interviews Erica Charters, Professor of the Global History of Medicine, 6 December 2021.
Topics discussed include (00:00:30) EC's early studies in the history of disease, doctorate at Oxford on the history of medicine (under Professor Mark Harrison, with particular interest in disease during the Seven Years' War), lecture post at Oxford from 2009; (00:01:40) interest in disease and the human experience; (00:02:47) long-term perspectives on disease and historical perspectives including social, cultural, political; (00:05:15) historic pandemics and Charles Rosenberg article “What is an Epidemic?” written during the AIDS epidemic; (00:07:50) tools used to explore the narrative of an epidemic; (00:10:12) first memory of COVID-19 in early 2020; (00:11:42) EC's research work and collaboration with other historians on COVID-19 and the relevance of history in understanding the pandemic; (00:14:23) Centaurus journal contributions [published by the European Society for the History of Science], work of Margaret Pelling (particularly relating to cholera in the 19th century) and work of anthropologists in East Africa [Wenzel, Geissler and Prince]; (00:16:05) COVID-19 specific research, online workshops 'How Epidemics End' (in collaboration with Kristin Heitman); (00:19:01) examples of epidemics ending (including Historian Sam Cohn's perspective, mathematical modelling, anthropologist perspectives); (00:23:10) concepts of excess deaths in disease and warfare; (00:27:20) grant applications for projects; (00:29:00) colleagues involved in policy work in terms of social responses to disease and public health restrictions; (00:31:15) working with health and medical practitioners and interdisciplinary research; (00:32:49) EC's personal experience of COVID-19 and the impact on the academic and research community; (00:34:31) impact on the well-being of students and colleagues, including remote teaching; (00:36:30) positives of online working, including broadening audiences internationally, online reading groups; (00:38:00) competing theories and frameworks in medical science; (00:39:41) EC's personal reaction to the threat from COVID-19; (00:41:40) working long hours and returning to the office; (00:43:32) maintaining productiveness and wellbeing through taking on the project; (00:44:57) how future historians might frame the global response to COVID-19; (00:47:55) future research interests owing to the pandemic, including how these events are measured; (00:50:30) changes in approach to work as a result of COVID-19.

Episode Information

Series
Collecting COVID: Oral Histories
People
Erica Charters
Georgina Ferry
Keywords
humanities
epidemics
epidemics and society
diseases and history
covid-19 (disease)
Department: Bodleian Libraries
Date Added: 29/07/2022
Duration: 00:52:06

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Professor Andy Pollard

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Collecting COVID: Oral Histories
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Georgina Ferry interviews Sir Andrew Pollard, Professor of Paediatric Infection and Immunity and Director of the Oxford Vaccine Group, 3 December 2021.
Topics discussed include (00:00:39) AP's early studies in medicine and route into the profession; (00:01:44) post-qualification work in A&E and training in paediatrics, PhD studies at St. Mary's, London and work in intensive care dealing with a new strain of meningitis in children, training in infectious disease in Canada and work in Oxford as part of the Oxford Vaccine Group; (00:05:30) work within the Oxford Vaccine Group including vaccine design and trials and current work on a vaccine for plague; (00:07:25) work on vaccine development for developing countries for infectious diseases, vaccine programmes on typhoid and pneumonia; (00:11:45) AP's first awareness of COVID-19 in early 2020, meeting of vaccine teams in Oxford to respond to the pandemic, work with Sarah Gilbert, Sandy Douglas and Teresa Lambe; (00:15:00) working together with different teams across the university; (00:16:30) clinical trials for the Oxford vaccine, recruitment of volunteers and the start of human trials in April 2020; (00:22:21) the commitment of vaccine trial volunteers; (00:23:05) Phase I trial and later phase trials; (00:24:30) effect of lockdown on the trial; (00:26:35) recruitment for Phase III trials nationally and internationally; (00:28:20) funding for trials in South Africa and Brazil; (00:28:58) partnership with AstraZeneca; (00:30:26) involvement with national bodies, including chairing the Joint Committee on Vaccines and Immunisation; (00:34:04) milestones in the trial process, including the first dose being administered, media attention, fake news, safety events; (00:40:48) the efficacy result of the vaccine trials; (00:45:32) AP's personal reaction to the results; (00:47:26) involvement in the vaccine roll out; (00:48:33) discussions relating to the nature of the vaccine as being not-for-profit, roll out to developing countries; (00:50:00) COVAX and distribution of the vaccine globally; (00:51:14) price of the vaccine; (00:52:29) experience of media scrutiny and first experience of a television interview; (00:54:30) social media and vaccine misinformation; (00:58:20) global vaccine equity; (01:00:00) vaccine boosters and new variants; (01:03:21) impact of the first lockdown on life and work, PPE provisions; (01:05:13) AP's personal response to the risk of COVID-19; (01:06:27) working hours and international collaboration; (01:07:30) personal well-being and resilience; (01:08:22) recreational activities; (01:09:01) team support and well-being; (01:10:14) knighthood for the Queen's Birthday Honours; (01:11:25) future research interests, including immune response and dosage and pandemic preparedness; (01:12:44) approach to work in the future. Note: the following section of audio is redacted (00:05:52) to (00:05:57).

Episode Information

Series
Collecting COVID: Oral Histories
People
Andy Pollard
Georgina Ferry
Keywords
medical sciences
immunology
clinical trials
clinical medicine
astrazeneca (firm)
covid-19 (disease)
Department: Bodleian Libraries
Date Added: 29/07/2022
Duration: 01:12:45

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Professor Cath Green

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Collecting COVID: Oral Histories
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Georgina Ferry interviews Catherine Green OBE, Head of the Clinical BioManufacturing Facility and Associate Professor in Chromosome Dynamics, 1 December 2021.
Topics discussed include (00:00:34) CG's early interest in science and studies in Cambridge, London and Paris and work in cancer research; (00:02:08) Clinical BioManufacturing Facility [CBF]; (00:04:45) CG's first memory of the emergence of COVID-19 in January 2020 and meeting with Professor Sarah Gilbert in late January relating to production of a vaccine; (00:06:06) manufacture of medicines and past work in manufacturing vaccines for Professor Gilbert, particularly the MERS vaccine; (00:07:37) CG's first response to the possible coronavirus vaccine project; (00:09:01) the process to begin the design and manufacture of the adenovirus vector vaccine beginning with a piece of the virus DNA code provided by Professors Gilbert and [Teresa] Lambe; (00:15:07) amplification of the cell culture for the vaccine starting material; (00:18:10) manufacture and clinical trial capacity at the CBF, work with Professor Andy Pollard in up-scaling trials, collaboration with Italian-based manufacturing site Advent and the chartering of a private jet to transport batches of trial vaccine doses to the U.K.; (00:23:32) work on other vaccine projects, including Nipah virus; (00:24:16) CG's personal response to and experience of COVID-19, including sending her daughter to key workers' school; (00:27:20) well-being of colleagues and balancing the needs of team members; (00:29:51) CG's concern over family members catching the virus; (00:31:16) CG's personal self-care and details of remote well-being activities; (00:33:33) involvement with national bodies including JCVI and MRHA; (00:34:12) emerging variants and vaccine alteration and involvement with AstraZeneca; (00:36:16) experience of press interviews with national newspapers and public speaking; (00:39:20) efficacy outcome for the first clinical trial data; (00:43:26) writing, publication and reception of 'Vaxxers' book with Professor Gilbert; (00:47:44) recognition and honours, including the Queen's Birthday Honours 2021 list; (00:50:30) women in science and the proportion of women working on the vaccine at Oxford; (00:52:30) questions Green is interested in exploring in the future, including regulatory background and manufacturing process, expansion of CBF and the general advancement of biological medicine manufacturing in the U.K.; (00:56:22) impact of the pandemic on the team, including changes to working on-site and remotely; (00:58:20) intensive working and returning to normal hours; (00:59:21) CG's reaction to her personal contribution to the development of a global vaccine; (01:00:27) continued supply of the vaccine to developing countries.

Episode Information

Series
Collecting COVID: Oral Histories
People
Cath Green
Georgina Ferry
Keywords
medical sciences
vaccines
viruses
astrazeneca (firm)
covid-19 (disease)
Department: Bodleian Libraries
Date Added: 29/07/2022
Duration: 01:01:19

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Professor Richard Hobbs

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Collecting COVID: Oral Histories
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Georgina Ferry interviews Richard Hobbs, Head of Department at the Nuffield Department of Primary Health Care Sciences and Nuffield Professor of Primary Care, 29 November 2021.
Topics discussed include (00:00:30) RH's early training as a GP and interest in cardiology, academic posts in Birmingham and Oxford; (00:02:32) RH's passion for primary care and general practice; (00:03:48) methods to explore questions in general practice and research interest in epidemiology, big data, clinical trials; (00:07:18) the importance of research in primary care, funding; (00:09:00) crises in NHS and general practice, including a lack of healthcare professionals in the community; (00:11:20) interest and research work in cardiovascular disease, particularly heart failure and atrial fibrillation; (00:17:09) RH's first memory of the emergence of COVID-19 and response taken by the medical school, freezing research programmes, clinical trial proposals relating to COVID-19; (00:21:48) PRINCIPLE [Platform Randomised Trial of Treatments in the Community for Epidemic and Pandemic Illnesses] and RECOVERY [Randomised Evaluation of COVID-19 Therapy] trials; (00:22:52) national screening programme on flu surveillance; (00:25:40) work by the Centre for Evidence-Based Medicine and publication of rapid reviews; (00:26:47) COVID risk score; (00:30:00) treatments explored in drug trials (00:32:30) PANORAMIC [Platform Adaptive trial of Novel antivirals for early treatment of COVID-19 in the Community] platform; (00:34:00) TACKLE [AstraZeneca] monoclonal antibody trial; (00:38:00) ivermectin trial and controversy; (00:44:00) the scientific debate in response to restrictions on freedoms; (00:47:50) Delta variant and the impact on the NHS; (00:51:00) national collaborations and partnerships; (00:56:35) respiratory infection and cardiovascular disease; (00:57:10) long-term implications of the pandemic on general practice and the health service; (01:01:25) national and global policy-making; (01:05:54) personal impact of the pandemic on work life, ability to travel, attendance at online conferences; (01:09:50) well-being of departmental colleagues; (01:11:43) the University's contribution to the world with regards to the pandemic response and development of a vaccine; (01:15:03) personal risk felt from COVID-19; (01:18:15) areas of interest for future research, including long COVID and digital assets; (01:20:38) the impact of COVID-19 on RH's approach to work.

Episode Information

Series
Collecting COVID: Oral Histories
People
Richard Hobbs
Georgina Ferry
Keywords
medical sciences
Primary Care
clinical trials
clinical medicine
public health
covid-19 (disease)
Department: Bodleian Libraries
Date Added: 29/07/2022
Duration: 01:22:51

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Professor Betty Raman

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Collecting COVID: Oral Histories
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Georgina Ferry interviews Betty Raman, Associate Professor of Cardiovascular Medicine, 16 November 2021.
Topics discussed include (00:00:53) an overview of BR's early interest in medicine, medical training whilst based in Adelaide, Australia and specialism in cardiology; (00:03:46) MRI technology; (00:05:28) BR's first awareness of the emergence of COVID-19 and meetings with mentor Professor Stefan Neubauer; (00:09:51) ability to continue research during the early stages of COVID-19, with the focus shifting to the pandemic; (00:11:15) work on national follow-up studies including PHOSP-COVID [Post-hospitalisation COVID-19]; (00:19:59) flu and COVID-19 and post-viral syndromes; (00:22:51) community patients recovering from COVID-19 with lingering symptoms; (00:25:33) personal experience of leading a multi-centre study; (00:27:19) long COVID and chronic fatigue syndrome; (00:29:22) experience of contracting COVID-19; (00:30:44) supply and shortages of PPE; (00:31:43) C-MORE study [Capturing the MultiORgan Effects of COVID-19]; (00:32:20) collaborative work on Xenon MRI research by professor Fergus Gleeson's lab; (00:35:11) changes in some institutions as a result of BR's work; (00:37:15) future research interests, particularly in terms of listening to the concerns of patients; (00:38:45) the importance of patient public engagement; (00:40:30) treatments being tested for patients with long COVID.

Episode Information

Series
Collecting COVID: Oral Histories
People
Betty Raman
Georgina Ferry
Keywords
medical sciences
cardiology
clinical medicine
covid-19 (disease)
Department: Bodleian Libraries
Date Added: 29/07/2022
Duration: 00:42:05

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Professor Sarah Walker

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Collecting COVID: Oral Histories
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Georgina Ferry interviews Sarah Walker, Professor of Medical Statistics and Epidemiology, 15 November 2021.
Topics discussed include (00:00:30) SW's studies in Medical Statistics and work in infectious diseases, HIV and bacterial infections; (00:02:44) SW's first awareness of COVID-19, work on a project in Vietnam and the implications of the disease for South East Asia; (00:05:01) the continuance of work during the lockdown period, including remote-working; (00:07:09) SW's initial reaction to COVID-19; (00:09:22) work with Professor Derrick Crook and Professor Tim Peto on Modernising Medical Microbiology; (00:10:40) seroprevalence study; (00:15:37) recruiting process for participants, in collaboration with the Office for National Statistics; (00:18:26) the pros and cons of measuring the pandemic through testing; (00:21:25) the evolution of the COVID-19 virus, including variants and mutations; (00:24:02) the continuation of the Office for National Statistics survey; (00:26:08) the level of protection afforded by the different vaccines and the challenges of asymptomatic infections; (00:29:25) reporting to Government on the ONS survey and influence on policy owing to this work; (00:30:32) involvement with Test and Trace; (00:32:39) public exposure relating to the publication of survey data each week; (00:34:10) SW's experience of media interviews; (00:35:36) viral load concept; (00:38:00) study focusing on healthcare workers and occupational infection data; (00:40:20) the path from scientific data to policy; (00:42:23) SW's personal experience of the pandemic and ability to work remotely; (00:43:52) hours of work during the pandemic; (00:44:40) SW's personal well-being and self-care; (00:45:50) well-being of the team; (00:48:15) future research interests, including the interplay between natural and acquired immunity and who is being hospitalised despite vaccination; (00:51:31) perspectives on balancing working from home and on-site and hopes for future changes to attitudes around this.

Episode Information

Series
Collecting COVID: Oral Histories
People
Sarah Walker
Georgina Ferry
Keywords
medical sciences
medical statistics
Epidemiology
covid-19 (disease)
Department: Bodleian Libraries
Date Added: 29/07/2022
Duration: 00:54:08

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Professor Paul Harrison

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Collecting COVID: Oral Histories
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Georgina Ferry interviews Paul Harrison, Professor of Psychiatry, 11 November 2021.
Topics discussed include (00:00:20) medical training, research interests; (00:01:10) techniques used to explore the question of the biological basis of serious mental illness; (00:02:10) PH's initial awareness of COVID-19; (00:02:51) practicalities of working during early COVID-19 restrictions; (00:03:44) repositioning of clinical work to focus on working with patients who had had COVID-19 and dealing with mental health sequelae; (00:06:35) the introduction of a 24/7 phone helpline and remote assessments for patients; (00:07:42) the problems patients presented with, particularly regarding the implications of lockdown and the pandemic; (00:08:43) research questions relating to the mental health of COVID-19 using real world data through an electronic health records network; (00:10:53) TriNetX and the collection of health data in the US; (00:12:50) work of trainee Max Taquet in analysing data; (00:13:20) first published papers relating to COVID-19 studies based upon database analysis; (00:16:03) study relating to connection between previous mental health diagnoses and COVID risk; (00:18:24) development of mental health illnesses after COVID-19 infections; (00:19:23) research into long COVID; (00:22:40) research into eating disorders as a result of the pandemic; (00:26:30) concerns relating to blood clots in relation to vaccines and utilising the TriNetX database to research risks of blood clots from both COVID-19 infection and vaccination; (00:29:38) funding of research; (00:31:01) changes to PH's personal life as a result of the pandemic, including working from home and conducting clinical work remotely; (00:32:02) the impact on students of Psychiatry and their involvement as volunteers; (00:33:29) medical student support and well-being and colleague well-being; (00:36:00) involvement in institutional preparation; (00:37:50) PH's personal well-being in relation to COVID research; (00:39:32) Government and authorities' handling of the pandemic; (00:41:25) involvement in follow-up COVID studies including PHOSP-COVID and COVID-CNS in the U.K.; (00:44:12) a study under review relating to the differences between catching COVID-19 when vaccinated and unvaccinated; (00:45:03) U.K. health database OpenSAFELY; (00:46:04) relationship between mental and physical health and the separation of physical and mental healthcare; (00:49:40) PH's participation on a voluntary basis in vaccine clinics.

Episode Information

Series
Collecting COVID: Oral Histories
People
Paul Harrison
Georgina Ferry
Keywords
medical sciences
psychiatry
mental health
covid-19 (disease)
Department: Bodleian Libraries
Date Added: 29/07/2022
Duration: 00:51:25

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Professor Derrick Crook

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Collecting COVID: Oral Histories
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Georgina Ferry interviews Derrick Crook, Professor of Microbiology, 9 November 2021.
Topics discussed include (00:00:30) an overview of Professor Crook's early medical training and route into clinical microbiology; (00:03:41) DC's first awareness of COVID-19 and its emergence in early 2020, references to the disease in the media and its initial perceived connection to SARS and other infectious diseases; (00:06:46) changes to work as a result of COVID-19 and work in other countries, including South Africa on cholera outbreaks; (00:08:20) development of COVID-19 mutations [lineages] and transmissibility; (00:13:50) Modernising Medical Microbiology research group and its work; (00:18:05) DC's interest in other infectious diseases prior to emergence of COVID-19 and research into the carrying of germs by healthy people into hospitals, antibiotic resistance; (00:23:09) computational analysis of the genetic code of Tuberculosis and mining of the code to find signatures of resistance and mutations, determining whether an organism is going to be resistant to anti-tuberculosis drugs; (00:26:54) work with Sarah [Walker], Tim [Peto] and John Bell on the response to COVID-19 and the setting up of the wide-scale testing platform required across the country; (00:28:34) Porton Down swab screening, manufacturing and supply problems, safety and standard of tests; (00:29:31) the development of an ELISA test to measure antibodies through the blood samples of infected people, work with the Government and Office for National Statistics (epidemiological survey); (00:32:02) work with Yvonne Jones on the test; (00:36:15) genomic research funded by Oracle; (00:37:00) Scalable Pathogen Pipeline Platform; (00:44:00) partnership with Oracle providing cloud infrastructure and software to configure tools and up-scale sequencing; (00:45:45) LamPORE study in collaboration with Oxford Nanopore; (00:51:30) setting up of SARS-CoV-2 sequencing in routine lab with sequence going through the Oracle cloud platform, with results going to Government.

Episode Information

Series
Collecting COVID: Oral Histories
People
Derrick Crook
Georgina Ferry
Keywords
medical sciences
communicable diseases
microbiology
rna viruses
covid-19 (disease)
Department: Bodleian Libraries
Date Added: 29/07/2022
Duration: 00:53:15

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