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Correlates of protection, the China Connection

Series
McMichael Symposium
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Professor Xiao-Ning Xu talks about his research on emerging infectious diseases in China, from the SARS outbreak in 2003/4 to flu pandemic and HIV infection.
Professor Xu also follows a HIV cohort in Beijing, and studies their T cell responses to the HIV conserved region. The stimulation of HIV-specific cytolytic T lymphocytes offers a new strategy for vaccine development.
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Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
McMichael Symposium
People
Xiao-Ning Xu
Keywords
Andrew McMichael
vaccine development
infectious diseases in China
Xiao-Ning Xu
Department: Nuffield Department of Clinical Medicine
Date Added: 28/10/2013
Duration: 00:26:50

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Time to escape

Series
McMichael Symposium
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Dr Nilu Goonetilleke talks about her research within the CHAVI project (NIH Center for HIV/AIDS Vaccine Immunology).
In the course of HIV infection, the fate is set early, since the early immune response is an important factor in determining the clinical course of the disease. Most patients are infected with a single transmitted founder virus. The first stages of the infection are of crucial importance: the first effective immune responses drive the selection of virus escape mutations. Strong innate and adaptive immune responses occur subsequently but they are too late to eliminate the infection.
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Episode Information

Series
McMichael Symposium
People
Nilu Goonetilleke
Keywords
Andrew McMichael
HIV/AIDS Vaccine Immunology
immunology
Nilu Goonetilleke
Department: Nuffield Department of Clinical Medicine
Date Added: 28/10/2013
Duration: 00:22:54

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African adventures

Series
McMichael Symposium
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Professor Sarah Rowland-Jones talks about her research on HIV, first in Oxford then in Africa, in Kenya and in The Gambia.
Professor Rowland-Jones studies protective immunity against HIV infection. It was early recognized that cytotoxic T cells play an important part in the control of HIV-1 infection; exposure to the less pathogenic HIV-2 strain leads to protection agains HIV-1 in people with a certain HLA type.
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Episode Information

Series
McMichael Symposium
People
Sarah Rowland-Jones
Keywords
Andrew McMichael
Sarah Rowland-Jones
immunology
hiv
Department: Nuffield Department of Clinical Medicine
Date Added: 28/10/2013
Duration: 00:31:58

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New immunoregulatory mechanisms

Series
McMichael Symposium
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Professor Mike Lenardo speaks about early links between the NIH (National Institute of Health, USA) and the University of Oxford, and their success in setting up the NIH-Oxford-Cambridge DPhil programme.
Professor Lenardo also talks about his work investigating immunological regulation and disorders using a human genetic approach.

Episode Information

Series
McMichael Symposium
People
Michael J Lenardo
Keywords
Andrew McMichael
immunology
genetics
Michael J. Lenardo
Department: Nuffield Department of Clinical Medicine
Date Added: 28/10/2013
Duration: 00:17:28

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A structural biologist's perspective

Series
McMichael Symposium
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Professor Yvonne Jones tells us how structural biology was brought into the field of immunology in Oxford, at the Wellcome Trust Centre for Human Genetics.
Professor Jones also explains the developments of her current research on cell surface receptors as mediators of nerve cells guidance.
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Episode Information

Series
McMichael Symposium
People
Yvonne Jones
Keywords
Andrew McMichael
immunology
Yvonne Jones
structural biology
Department: Nuffield Department of Clinical Medicine
Date Added: 28/10/2013
Duration: 00:15:07

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What do we measure and what do we want to learn

Series
McMichael Symposium
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Professor Zinkernagel speaks about some historical and more recent aspects of immunology. Although we do know a lot, only about half of what we think we know is usually true - we just don't know which half!
Professor Zinkernagel differentiates between scientists who beg for the question and scientists who observe. Scientists can not do better than evolution by using the same tools, only when introducing 'new' tools (antibiotics, antivirals, autoantibodies). Scientists also need to keep in mind that, eventually, the patient is always right.
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Episode Information

Series
McMichael Symposium
People
Rolf Zinkernagel
Keywords
Andrew McMichael
Rolf Zinkernagel
immunology
Department: Nuffield Department of Clinical Medicine
Date Added: 28/10/2013
Duration: 00:35:27

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Welcome and Introduction

Series
McMichael Symposium
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Professor Vincenzo Cerundolo opens the Symposium with a few words about Professor Sir Andrew McMichael's achievements, past, present and future.
Professor Vincenzo Cerundolo talks about Professor Sir Andrew McMichael and his tremendous vision, his contagious enthusiam, his ability to motivate and inspire and his legacy that goes beyond his scientific achievements.
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Episode Information

Series
McMichael Symposium
People
Vincenzo Cerundolo
Keywords
Andrew McMichael
Vincenzo Cerundolo
Department: Nuffield Department of Clinical Medicine
Date Added: 28/10/2013
Duration: 00:04:23

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Men at War: What Fiction Tells Us About War

Series
Changing Character of War
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Professor Christopher Coker looks at the presentation of war in fiction, focussing in particular on the different character types commonly portrayed.
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Episode Information

Series
Changing Character of War
People
Christopher Coker
Keywords
Achilles
Flashman
tolstoy
war
fiction
Department: Pembroke College
Date Added: 28/10/2013
Duration: 00:54:23

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Displacement from Syria: putting the Common European Asylum System to the test?

Series
Refugee Studies Centre
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Special lecture, Michaelmas term 2013. Lecture by Madeline V Garlick (UNHCR) recorded on 24 October 2013 at the Oxford Department of International Development, University of Oxford.
In this lecture, Madeline Garlick analyses the trends in arrivals, recognition rates and other responses to date to Syrians claiming protection in and at the borders of the EU. She questions whether the Common European Asylum System has proven its ability to deliver swift and consistent protection to those in need, as foreseen in the Treaties and successive political declarations, in the face of widespread and well-documented persecution, extreme violence and horrifying violations of human rights.
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Episode Information

Series
Refugee Studies Centre
People
Madeline V Garlick
Keywords
europe
migration
EU
syria
borders
forced migration
refugees
conflict
Department: Oxford Department of International Development
Date Added: 25/10/2013
Duration: 00:46:58

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Survival migration: failed governance and the crisis of displacement

Series
Refugee Studies Centre
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Public Seminar Series, Michaelmas term 2013. Seminar by Dr Alexander Betts (University of Oxford) recorded on 16 October 2013 at the Oxford Department of International Development, University of Oxford.
The talk, based on Betts new book, will explore the challenge of responding to new drivers of cross-border displacement that fall outside the existing refugee framework. Rather than beginning with particular causes of displacement, whether environmental change, food insecurity or generalized violence, it offers a human rights-based framework through which to critically consider who, in a changing world, should be entitled to cross an international border and seek asylum. Based on extensive fieldwork, it grounds its analysis in an exploration of contemporary flight from three of the most fragile states in the world: Zimbabwe, the Democratic Republic of Congo and Somalia. It explains the massive variation in national and international institutional responses in the neighbouring states, arguing that politics rather than law ultimately determines how the refugee regime is implemented in practice.
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Episode Information

Series
Refugee Studies Centre
People
Alexander Betts
Keywords
human rights
refugee law
refugees
Governance
zimbabwe
protection
migration
drc
Democratic Republic of Congo
somalia
Department: Oxford Department of International Development
Date Added: 25/10/2013
Duration: 00:53:02

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