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Drug Discovery: Your questions

Series
NDM Public Engagement
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How does medicine work? How are new drugs made? What role does the pharmaceutical industry play? Professors Stefan Knapp and Chas Bountra joined Science Oxford Live in spring 2013 for an evening of Scientists on the sofa, to take your questions.
Have you really got a model for how this ought to work? I wanted to comment about the publication of negative findings. Have you been involved? What is your view on this? How quickly do you think it will happen? You spoke about the research institutes closing down; are they closing down in the UK and relocating, or are they just closing? Is there something to be said for slowing, or stopping, research for diseases of old age, for example Alzheimer's, and instead concentrating on scanning the genome of very young human beings to see what they might get in their future years? In regards to what you were saying about people reacting differently to a drug; that must mean that for a long time doctors have been prescribing things that don't work, and nobody's admitted it? Is that right? Because we are all so very different?
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Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
NDM Public Engagement
People
Stefan Knapp
Chas Bountra
Keywords
genone sequencing
drug discovery
new medicines
Department: Nuffield Department of Clinical Medicine
Date Added: 16/07/2013
Duration: 00:09:17

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Freeing Voices

Series
NDM Public Engagement
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Specific Language Impairment affects hundreds of thousands of British children, and causes them to have difficulties speaking and understanding language.
Unlike common speech and language disorders, Specific Language Impairment (SLI), is the impairment of acquisition and language use, which is severe, persistent and often unexpected. SLI is hereditary and is typical of a complex genetic disorder, where certain combinations of functional variants result in less efficient biological processes.
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Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
NDM Public Engagement
People
Dianne Newbury
Keywords
specific language impairment
Freeing Voices
language use
Department: Nuffield Department of Clinical Medicine
Date Added: 16/07/2013
Duration: 00:24:32

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Drug Discovery

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NDM Public Engagement
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How does medicine work? How are new drugs made? What role does the pharmaceutical industry play? Professors Stefan Knapp and Chas Bountra work in the field of drug discovery. They joined Science Oxford talks in spring 2013.
Society is increasingly desperate for novel medicine. Most drugs used today were developed more than 40 years ago. With our ageing population, the incidence of diseases such as dementia, cardiovascular disease, and cancer will increase exponentially over the coming years.
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Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
NDM Public Engagement
People
Chas Bountra
Keywords
genone sequencing
drug discovery
new medicines
Department: Nuffield Department of Clinical Medicine
Date Added: 16/07/2013
Duration: 00:16:49

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Discovery of new medicines and the future of drug development

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NDM Public Engagement
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How does medicine work? How are new drugs made? What role does the pharmaceutical industry play? Professors Stefan Knapp and Chas Bountra work in the field of drug discovery. They joined Science Oxford talks in spring 2013.
Over the past 30 to 40 years there have been drastic changes in the way new medicines are developed. Before the 1970s drug development was based on phenotypic assays and 'accidental findings', with an approval process that would often take two to three years to complete. Scientists now have a better understanding of the mechanisms leading to disease development, allowing the selection of 'targets' - regulators which are dysfunctional in the disease - allowing scientists to develop new drugs, which inhibit these cellular targets.
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Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
NDM Public Engagement
People
Stefan Knapp
Keywords
genone sequencing
drug discovery
new medicines
Department: Nuffield Department of Clinical Medicine
Date Added: 16/07/2013
Duration: 00:11:59

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A behavioural perspective of translating evidence to policy and practice

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Evidence-Based Health Care
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Susan Michie, Professor of Health Psychology, UCL, gives a talk at Kellogg College for the Centre for Evidence Based Medicine.
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Episode Information

Series
Evidence-Based Health Care
People
Susan Michie
Keywords
Medicine
health policy
Health
psychology
Department: Medical Sciences Division
Date Added: 16/07/2013
Duration: 00:54:49

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A behavioural perspective of translating evidence to policy and practice

Series
Kellogg College
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Susan Michie, Professor of Health Psychology, UCL, gives a talk at Kellogg College for the Centre for Evidence Based Medicine.
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Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Kellogg College
People
Susan Michie
Keywords
Medicine
health policy
Health
psychology
Department: Kellogg College
Date Added: 16/07/2013
Duration: 00:54:49

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How Youtube is being used as a platform to share opinions and experiences of a controversial treatment for Multiple Sclerosis

Series
Evidence-Based Health Care
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Brandon O'Neill, DPhil Candidate, PCHS, gives a lecture on treating Multiple Sclerosis and how social media is being used to share experiences of patients.
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Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Evidence-Based Health Care
People
Brandon O'Neill
Keywords
social media
patient treatment
YouTube
Health
Medicine
Multiple sclerosis
Department: Medical Sciences Division
Date Added: 16/07/2013
Duration: 00:40:19

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Who Leads, Who Follows? A Multi-level Perspective of Energy Transitions in the Transport Sector

Series
Transport Studies Unit Podcasts
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Part of the Transitioning towards Electric Vehicles seminar series held at the Transport Studies Unit of the Oxford University Centre for the Environment.
The electrification of the vehicle fleet involves a mass of actions to be taken by European, national and local government, a range of industries and consumers. It involves coordination between transport and energy policy if the benefits of decarbonisation are to be realised. The changes must also fit (and compete for resources) with broader policy imperatives such as the economy and health. This talk draws on results from a study of climate change governance which explored the roles and expectations of decision-makers in different organisations at different governance levels working upwards and outwards from four city regions in England and Scotland. It examines the balance between bottom up innovation and top-down steering and makes recommendations about the sorts of policy tools that may facilitate or accelerate uptake and the policy pre-conditions that must support these.
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Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Transport Studies Unit Podcasts
People
Greg Marsden
Keywords
electric transport
climate change
electric cars
society
technology
transport
Department: Oxford University Centre for the Environment
Date Added: 15/07/2013
Duration: 00:36:46

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Social Sustainability in Transport - Cinderella Shall Go To the Ball.

Series
Kellogg College
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This lecture by Dr Karen Lucas conceptualises the social dimensions of the sustainability paradigm and offers a discussion of why it is so important to achieve socially sustainable mobility in our towns and cities.
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Episode Information

Series
Kellogg College
People
Karen Lucas
Keywords
sustainability
climate
infrastructure
transport
Department: Kellogg College
Date Added: 12/07/2013
Duration: 00:21:26

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Tower Poetry 2013: Research

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Tower Poetry
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Luke van den Barselaar reads his entry for the 2013 Tower Poetry Competition.

Episode Information

Series
Tower Poetry
People
Luke van den Barselaar
Keywords
tower poetry
literature
poetry
Department: Christ Church
Date Added: 10/07/2013
Duration: 00:01:24

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