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Targeting cancer mechanisms

Series
Translational Medicine
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Professor Robert Gilbert's research focuses on the molecular mechanisms underlying membrane pore formation and cell adhesion.
Switching mechanisms within our cells are in part responsible for their development. MicroRNAs control a whole set of proteins associated with stem cell biology, particularly cancer stem cells. Targeting these components raises the potential for new anti-cancer therapeutics, which work by switching off protein production rather than inhibiting them later.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Translational Medicine
People
Robert Gilbert
Keywords
molecular
cell membranes
cell adhesion
cancer
stem cells
Department: Nuffield Department of Clinical Medicine
Date Added: 07/01/2016
Duration: 00:05:46

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Inflammation in disease

Series
Translational Medicine
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The main aim of Dr Xue's research is to understand the molecular and cellular mechanisms mediating inflammatory diseases, and to translate their findings into therapeutic concepts to treat these diseases.
Drugs and treatments for inflammatory diseases are scarce and often induce major side effects. A better understanding of the molecular mechanisms governing inflammatory diseases would allow us to develop new drug and treatments, at great benefit for both patients and the NHS.

Episode Information

Series
Translational Medicine
People
Luzheng Xue
Keywords
molecular
cellular
inflammatory disease
drug development
Department: Nuffield Department of Clinical Medicine
Date Added: 07/01/2016
Duration: 00:05:06

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Computation and genetics

Series
Translational Medicine
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Resistance to drugs in bacteria can be aquired by swapping genes between individual bacteria. Computer programs developed by Dr Iqbal enable doctors to predict which antibiotics will be met with drug resistance, enabling the selection of the right drug.
BIOINFORMATICS & PATHOGEN GENOMICS
Dr Zamin Iqbal studies the DNA of bacteria and parasites, and compares the genomes of individual pathogens to track the spread of antibiotic resistance. Pathogens accumulate small genetic changes over time, and by tracking these changes, it is possible to map the spread of an infection. This enables better surveillance of pathogen evolution, within a host, within a hospital and across the world.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Translational Medicine
People
Zamin Iqbal
Keywords
computational
genetics
bioinformatics
pathogens
drug resistance
DNA
antibiotic resistance
Department: Nuffield Department of Clinical Medicine
Date Added: 07/01/2016
Duration: 00:04:25

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Targeting cancer mechanisms

Series
Cancer
Embed
Professor Robert Gilbert's research focuses on the molecular mechanisms underlying membrane pore formation and cell adhesion.
Switching mechanisms within our cells are in part responsible for their development. MicroRNAs control a whole set of proteins associated with stem cell biology, particularly cancer stem cells. Targeting these components raises the potential for new anti-cancer therapeutics, which work by switching off protein production rather than inhibiting them later.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Cancer
People
Robert Gilbert
Keywords
molecular
cell membranes
cell adhesion
cancer
stem cells
Department: Nuffield Department of Clinical Medicine
Date Added: 07/01/2016
Duration: 00:05:46

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Inflammation in disease

Series
Translational and Clinical
Embed
The main aim of Dr Xue's research is to understand the molecular and cellular mechanisms mediating inflammatory diseases, and to translate their findings into therapeutic concepts to treat these diseases.
Drugs and treatments for inflammatory diseases are scarce and often induce major side effects. A better understanding of the molecular mechanisms governing inflammatory diseases would allow us to develop new drug and treatments, at great benefit for both patients and the NHS.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Translational and Clinical
People
Luzheng Xue
Keywords
molecular
cellular
inflammatory disease
drug development
Department: Nuffield Department of Clinical Medicine
Date Added: 07/01/2016
Duration: 00:05:06

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Computation and genetics

Series
Genetics
Embed
Resistance to drugs in bacteria can be aquired by swapping genes between individual bacteria. Computer programs developed by Dr Iqbal enable doctors to predict which antibiotics will be met with drug resistance, enabling the selection of the right drug.
BIOINFORMATICS & PATHOGEN GENOMICS
Dr Zamin Iqbal studies the DNA of bacteria and parasites, and compares the genomes of individual pathogens to track the spread of antibiotic resistance. Pathogens accumulate small genetic changes over time, and by tracking these changes, it is possible to map the spread of an infection. This enables better surveillance of pathogen evolution, within a host, within a hospital and across the world.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Genetics
People
Zamin Iqbal
Keywords
computational
genetics
bioinformatics
pathogens
drug resistance
DNA
antibiotic resistance
Department: Nuffield Department of Clinical Medicine
Date Added: 07/01/2016
Duration: 00:04:25

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Seeing the High Energy Universe with IceCube

Series
Oxford Physics Public Lectures
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Members of the Rudolf Peierls Centre for Theoretical Physics hosted the 3rd morning of Theoretical Physics covering the subject of Inner Space Meets Outer Space: Covering the Connections Between Cosmology and Particle Physics

Episode Information

Series
Oxford Physics Public Lectures
People
Subir Sarkar
Keywords
rudolf peierls centre
theoretical physics
Physics
IceCube Neutrino Observatory
neutrinos
black holes
gamma-ray bursts
Department: Department of Physics
Date Added: 06/01/2016
Duration: 00:44:21

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Genomic revolution and its impact on prostate cancer care

Series
Surgical Grand Rounds Lectures
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Professor Ash Tewari talks about the genomics of prostate cancer and the implications for managing high risk disease.
Professor Tewari is a world-renowned urologist and prostate cancer specialist. As Director of the Department of Urology at the Icahn School of Medicine at Mount Sinai Hospital in New York, he leads a multidisciplinary team committed to improving prostate cancer treatment, research and education.

Episode Information

Series
Surgical Grand Rounds Lectures
People
Ash Tewari
Keywords
surgery
prostate
cancer
genomics
Department: Nuffield Department of Surgical Sciences
Date Added: 05/01/2016
Duration: 00:42:00

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Surgical Grand Rounds Lectures

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Surgical Grand Rounds Lectures
The Surgical Grand Rounds, hosted by the Nuffield Department of Surgical Sciences, are the key educational meetings for consultants, juniors and medical students. Presentations revolve around clinical cases and are followed by lively, educational discussion. These podcasts are brought to you by the Oxford University Medical Education Fellows.

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Framing the Past through Suffering and Victimhood – Kurdish Discourses of Identity

Series
TORCH | The Oxford Research Centre in the Humanities
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Christine Allison gives a talk as part of The Long History of Identity, Ethnicity, and Nationhood workshop
This paper arises out of a monograph I am writing on how the Kurds talk about the past. The ideas of Kurdish suffering and Kurdish victimhood are fundamental to the way Kurdish identity is constructed, both in the Kurdish homelands and the diaspora. This is also the case for Kurdish collective memory (which is intimately linked to Kurdish identity). Clearly Kurds have indeed suffered many violent events over the past century, but this is not at issue – what I examine here is how events of the past have been mediated into discourse. Kurdish narratives of the past tend to emphasise Kurdish suffering and victimhood, rather than Kurdish victories and achievements, and in this paper I will outline how this discourse of memory is formed, who is forming it, and why – what social and political purposes does it serve to frame the past in this way?

Episode Information

Series
TORCH | The Oxford Research Centre in the Humanities
People
Christine Allison
Keywords
politics
Kurdish
identity
middle east
Department: The Oxford Research Centre in the Humanities (TORCH)
Date Added: 05/01/2016
Duration: 00:23:08

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