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Membrane proteins and drug development

Series
Translational and Clinical
Embed
Dr Liz Carpenter talks about her research on membrane proteins and drug development.
Membrane proteins are the gateways to our cells - with nutrients, waste products, and even DNA and proteins entering and leaving cells via these tightly controlled proteins. Drugs often target membrane proteins; therefore, understanding their molecular structure helps us design better drugs. Dr Liz Carpenter uses X-ray crystallography to solve membrane protein structures. This information is then used to improve treatments for heart disease and neurological diseases.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Translational and Clinical
People
Liz Carpenter
Keywords
membrane proteins
protein structure
high-throughput
drug discovery
ion channel
x-ray crystallography
Department: Nuffield Department of Clinical Medicine
Date Added: 29/04/2013
Duration: 00:05:01

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Membrane proteins and drug development

Series
Translational Medicine
Embed
Dr Liz Carpenter talks about her research on membrane proteins and drug development.
Membrane proteins are the gateways to our cells - with nutrients, waste products, and even DNA and proteins entering and leaving cells via these tightly controlled proteins. Drugs often target membrane proteins; therefore, understanding their molecular structure helps us design better drugs. Dr Liz Carpenter uses X-ray crystallography to solve membrane protein structures. This information is then used to improve treatments for heart disease and neurological diseases.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Translational Medicine
People
Liz Carpenter
Keywords
membrane proteins
protein structure
high-throughput
drug discovery
ion channel
x-ray crystallography
Department: Nuffield Department of Clinical Medicine
Date Added: 29/04/2013
Duration: 00:05:01

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MedicineAfrica

Series
Global Health
Embed
Dr Alexander Finlayson tells us how MedicineAfrica aims to bring healthcare professionals around the world in a global expert network.
Disparity in healthcare between the developed and developing world is a major global health problem. MedicineAfrica, an online health facility, aims to connect doctors and healthcare professionals in Africa to clinical support teams around the world. Dr Alexamder Finlayson established MedicineAfrica in 2008, and is now working to develop this platform for future users, such as medical students, doctors and nurses, in other countries including Palestine and India.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Global Health
People
Alexander Finlayson
Keywords
global health
communication
Africa
capacity building
Department: Nuffield Department of Clinical Medicine
Date Added: 29/04/2013
Duration: 00:06:12

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MedicineAfrica

Series
Translational Medicine
Embed
Dr Alexander Finlayson tells us how MedicineAfrica aims to bring healthcare professionals around the world in a global expert network.
Disparity in healthcare between the developed and developing world is a major global health problem. MedicineAfrica, an online health facility, aims to connect doctors and healthcare professionals in Africa to clinical support teams around the world. Dr Alexamder Finlayson established MedicineAfrica in 2008, and is now working to develop this platform for future users, such as medical students, doctors and nurses, in other countries including Palestine and India.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Translational Medicine
People
Alexander Finlayson
Keywords
global health
communication
Africa
capacity building
Department: Nuffield Department of Clinical Medicine
Date Added: 29/04/2013
Duration: 00:06:12

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Structural cell biology of virus infection

Series
Immunology
Embed
Professor Kay Grunewald tells us how structural cell biology can help us understand virus infection.
Cells constitute the smallest autonomous units of life. The tightly regulated structural and functional organisation is currently only rudimentary understood. Professor Kay Grünewald uses electron cryotomography in combination with other techniques to analyse virus' 'life cycle' in situ, which requires an understanding of its transient structures at the molecular level. Imaging techniques allow us to understand the communication between the virus and the components of the cell it is infecting, which can ultimately help to treat infectious diseases.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Immunology
People
Kay Grunewald
Keywords
membrane proteins
cell biology
microscopy
electron
virus-host interaction
tomography
Department: Nuffield Department of Clinical Medicine
Date Added: 29/04/2013
Duration: 00:06:25

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Structural cell biology of virus infection

Series
Translational Medicine
Embed
Professor Kay Grunewald tells us how structural cell biology can help us understand virus infection.
Cells constitute the smallest autonomous units of life. The tightly regulated structural and functional organisation is currently only rudimentary understood. Professor Kay Grünewald uses electron cryotomography in combination with other techniques to analyse virus' 'life cycle' in situ, which requires an understanding of its transient structures at the molecular level. Imaging techniques allow us to understand the communication between the virus and the components of the cell it is infecting, which can ultimately help to treat infectious diseases.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Translational Medicine
People
Kay Grunewald
Keywords
membrane proteins
cell biology
microscopy
electron
virus-host interaction
tomography
Department: Nuffield Department of Clinical Medicine
Date Added: 29/04/2013
Duration: 00:06:25

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Molecular immunology

Series
Immunology
Embed
Dr Christian Eggeling tells us how new imaging methods help us understand immunology at the molecular level.
To study complex biological and immunological systems, such as living cells, scientists rely on highly sensitive and non-invasive analysis techniques. Super-resolution optical microscopy allows us to study immunological processes on the molecular level. We can get new insights into how our body reacts to viral or bacterial attacks. Dr Christian Eggeling's research focuses on the application and development of superior, ultra-sensitive, live-cell fluorescence microscopy techniques. This has the potential to help us design new drugs and developing new ways of treating diseases.

Episode Information

Series
Immunology
People
Christian Eggeling
Keywords
in vivo imaging
drug discovery
immunology
microscopy
fluorescence
Department: Nuffield Department of Clinical Medicine
Date Added: 29/04/2013
Duration: 00:04:04

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Molecular immunology

Series
Translational Medicine
Embed
Dr Christian Eggeling tells us how new imaging methods help us understand immunology at the molecular level.
To study complex biological and immunological systems, such as living cells, scientists rely on highly sensitive and non-invasive analysis techniques. Super-resolution optical microscopy allows us to study immunological processes on the molecular level. We can get new insights into how our body reacts to viral or bacterial attacks. Dr Christian Eggeling's research focuses on the application and development of superior, ultra-sensitive, live-cell fluorescence microscopy techniques. This has the potential to help us design new drugs and developing new ways of treating diseases.

Episode Information

Series
Translational Medicine
People
Christian Eggeling
Keywords
in vivo imaging
drug discovery
immunology
microscopy
fluorescence
Department: Nuffield Department of Clinical Medicine
Date Added: 29/04/2013
Duration: 00:04:04

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The lymphatic system in immunity and cancer

Series
Immunology
Embed
Professor David Jackson tells us about the role of the lymphatic system in immunity and cancer.
The lymphatic system is a network of vessels collecting the fluids leaked from the blood vasculature. Its filtering function makes it an ideal compartment for the immune system. It is also a pipeline for metastasizing tumour cells to spread to distant tissues. Professor David Jackson studies how leukocytes and tumour cells enter the lymphatic vessels from the surrounding tissues. Professor Jackson's research has the potential to help us better control the spread of tumours, block unwanted immune responses in autoimmune diseases, block tissue rejection and make vaccines more effective.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Immunology
People
David Jackson
Keywords
lymph node
tumour
immunology
cancer
metastasis
lymphatic system
Department: Nuffield Department of Clinical Medicine
Date Added: 29/04/2013
Duration: 00:07:21

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The lymphatic system in immunity and cancer

Series
Translational Medicine
Embed
Professor David Jackson tells us about the role of the lymphatic system in immunity and cancer.
The lymphatic system is a network of vessels collecting the fluids leaked from the blood vasculature. Its filtering function makes it an ideal compartment for the immune system. It is also a pipeline for metastasizing tumour cells to spread to distant tissues. Professor David Jackson studies how leukocytes and tumour cells enter the lymphatic vessels from the surrounding tissues. Professor Jackson's research has the potential to help us better control the spread of tumours, block unwanted immune responses in autoimmune diseases, block tissue rejection and make vaccines more effective.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Translational Medicine
People
David Jackson
Keywords
lymph node
tumour
immunology
cancer
metastasis
lymphatic system
Department: Nuffield Department of Clinical Medicine
Date Added: 29/04/2013
Duration: 00:07:21

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