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Molecular immunology

Series
Translational Medicine
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Dr Christian Eggeling tells us how new imaging methods help us understand immunology at the molecular level.
To study complex biological and immunological systems, such as living cells, scientists rely on highly sensitive and non-invasive analysis techniques. Super-resolution optical microscopy allows us to study immunological processes on the molecular level. We can get new insights into how our body reacts to viral or bacterial attacks. Dr Christian Eggeling's research focuses on the application and development of superior, ultra-sensitive, live-cell fluorescence microscopy techniques. This has the potential to help us design new drugs and developing new ways of treating diseases.

Episode Information

Series
Translational Medicine
People
Christian Eggeling
Keywords
in vivo imaging
drug discovery
immunology
microscopy
fluorescence
Department: Nuffield Department of Clinical Medicine
Date Added: 29/04/2013
Duration: 00:04:04

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The lymphatic system in immunity and cancer

Series
Immunology
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Professor David Jackson tells us about the role of the lymphatic system in immunity and cancer.
The lymphatic system is a network of vessels collecting the fluids leaked from the blood vasculature. Its filtering function makes it an ideal compartment for the immune system. It is also a pipeline for metastasizing tumour cells to spread to distant tissues. Professor David Jackson studies how leukocytes and tumour cells enter the lymphatic vessels from the surrounding tissues. Professor Jackson's research has the potential to help us better control the spread of tumours, block unwanted immune responses in autoimmune diseases, block tissue rejection and make vaccines more effective.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Immunology
People
David Jackson
Keywords
lymph node
tumour
immunology
cancer
metastasis
lymphatic system
Department: Nuffield Department of Clinical Medicine
Date Added: 29/04/2013
Duration: 00:07:21

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The lymphatic system in immunity and cancer

Series
Translational Medicine
Embed
Professor David Jackson tells us about the role of the lymphatic system in immunity and cancer.
The lymphatic system is a network of vessels collecting the fluids leaked from the blood vasculature. Its filtering function makes it an ideal compartment for the immune system. It is also a pipeline for metastasizing tumour cells to spread to distant tissues. Professor David Jackson studies how leukocytes and tumour cells enter the lymphatic vessels from the surrounding tissues. Professor Jackson's research has the potential to help us better control the spread of tumours, block unwanted immune responses in autoimmune diseases, block tissue rejection and make vaccines more effective.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Translational Medicine
People
David Jackson
Keywords
lymph node
tumour
immunology
cancer
metastasis
lymphatic system
Department: Nuffield Department of Clinical Medicine
Date Added: 29/04/2013
Duration: 00:07:21

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Cutaneous immunology

Series
Immunology
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Professor Graham Ogg talks about the role of our skin as a barrier against infection.
Skin frequently represents the first point of contact with pathogens and allergens, but there is still very little known about the role of the surface immune system in fighting unwanted invaders. Barrier dysfunction can lead to the development of eczema. Understanding these mechanisms can help us develop new treatments targeting the skin, as well as the inflammatory response. Dr Graham Ogg aims to understand the role of skin immune responses by studying common skin diseases and infections.

Episode Information

Series
Immunology
People
Graham Ogg
Keywords
eczema
atopic disease
T-cell
immunology
skin
Department: Nuffield Department of Clinical Medicine
Date Added: 29/04/2013
Duration: 00:06:02

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Cutaneous immunology

Series
Translational Medicine
Embed
Professor Graham Ogg talks about the role of our skin as a barrier against infection.
Skin frequently represents the first point of contact with pathogens and allergens, but there is still very little known about the role of the surface immune system in fighting unwanted invaders. Barrier dysfunction can lead to the development of eczema. Understanding these mechanisms can help us develop new treatments targeting the skin, as well as the inflammatory response. Dr Graham Ogg aims to understand the role of skin immune responses by studying common skin diseases and infections.

Episode Information

Series
Translational Medicine
People
Graham Ogg
Keywords
eczema
atopic disease
T-cell
immunology
skin
Department: Nuffield Department of Clinical Medicine
Date Added: 29/04/2013
Duration: 00:06:02

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Gut reactions

Series
Autoimmune Disease
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Professor Fiona Powrie talks about the importance of our guts, and her research in gastroenterology.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Autoimmune Disease
People
Fiona Powrie
Keywords
bowel disease (IBD)
protective immunity
inflammation
gastroenterology
Department: Nuffield Department of Clinical Medicine
Date Added: 29/04/2013
Duration: 00:04:28

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Fiona Powrie

Series
Translational Medicine
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Professor Fiona Powrie talks about the importance of our guts, and her research in gastroenterology.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Translational Medicine
People
Fiona Powrie
Keywords
bowel disease (IBD)
protective immunity
inflammation
gastroenterology
Department: Nuffield Department of Clinical Medicine
Date Added: 29/04/2013
Duration: 00:04:28

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Translational and Clinical

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Translational and Clinical Medicine is the ongoing effort to bring basic science from the bench to the patient, as well as to elucidate safety and effectiveness of the medicines on which we depend. The NDM podcasts on translational and clinical medicine detail our work in this wide-ranging field, from the identification and design of new medicines to clinical trials and trial design and regulation.

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Genetics

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Genetics
We are all products of our genes, and Genetics is a major focus of NDM research. Our podcasts on genetics look at a variety of projects, including the study of some common and less-common inherited afflictions, as well as the effects our genes can have on disease susceptibility and the efficacy of treatment. Moreover, NDM researchers lead in studying the genetic variation within and between human populations, to understand the similarities and differences between us all.

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Diabetes and Obesity

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Diabetes and Obesity
Obesity and diabetes are increasingly a burden in modern populations, and whilst the contributions of our lifestyles are well-known, other aspects of the conditions are less clear. Our podcasts on diabetes and obesity highlight the work of our scientists and clinicians to understand the underlying factors of lifestyle and metabolism, molecular and genetic mechanisms, and less common forms of diabetes, to improve management and treatment of these conditions.

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