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Epigenetic modifications and cancer

Series
Translational Medicine
Embed
Professor Skirmantas Kriaucionis aims to to elucidate the molecular function of DNA modifications in normal cells and cancer.
Although all cells in our body have the same genome, they look different and perform different functions. Epigenetic modifications such as methylations ensure which sets of genes are expressed in specific cells and how this specificity is inherited. Cancer cells show particular epigenetic abnormalities which can be targeted for cancer therapies.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Translational Medicine
People
Skirmantas Kriaucionis
Keywords
cancer
Epigenetics
DNA
molecules
cells
genome
Department: Nuffield Department of Clinical Medicine
Date Added: 14/12/2016
Duration: 00:05:44

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Fighting malaria in Myanmar

Series
Translational Medicine
Embed
Professor Frank Smithuis is the director of MOCRU, Myanmar Oxford Clinical Research Unit. MOCRU involves a network of 6 clinics and 650 community health workers in remote areas.
Up until now, Myanmar has spent little on heathcare and receive little assistance from rich countries. Prevention is difficult, which leaves diagnosis and treatment. MOCRU has set up a network of community health workers, trained and supplied with diagnostics and treatments, to help improve access to healthcare for remote communities.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Translational Medicine
People
Frank Smithuis
Keywords
malaria
myanmar
clinical research
community health
diagnosis
treatment
Department: Nuffield Department of Clinical Medicine
Date Added: 14/12/2016
Duration: 00:06:44

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Optimising malaria treatment

Series
Malaria
Embed
Dr Georgina Humphreys coordinates the WorldWide Antimalarial Resistance Network (WWARN) study groups by encouraging partner engagement and managing the data curation and development of publications.
WWARN is a network of research that analyses pooled data of numerous clinical trials. The sheer size of those data sets allows study groups to answer questions that couldn't be asked of a normal size clinical trial, such as the efficacy of an anti-malarial drug on malnourished or severely anaemic children. This research helps design policies to maintain the efficacy of current anti-malaria drugs, currently threatened by growing resistance.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Malaria
People
Georgina Humphreys
Keywords
malaria
treatment
data curation
clinical trials
drug resistance
Department: Nuffield Department of Clinical Medicine
Date Added: 14/12/2016
Duration: 00:06:13

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Outbreak, the clinical research response

Series
Global Health
Embed
Dr Gail Carson is Head of ISARIC Coordinating Centre (International Severe Acute Respiratory and Emerging Infection Consortium), a network of networks established in 2011 to ensure a rapid research response to outbreaks of pandemic potential.
A quick and efficient response to an outbreak requires strong central communication and coordination. Information needs to be shared quickly and then fed into patient care and policy. A wider approach, cutting across disciplines and specialities, helps limit the number of infected people and the impact on the economy.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Global Health
People
Gail Carson
Keywords
clinical research
outbreak
network
pandemics
response
communication
data sharing
Department: Nuffield Department of Clinical Medicine
Date Added: 14/12/2016
Duration: 00:04:41

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Epigenetic modifications and cancer

Series
Cancer
Embed
Professor Skirmantas Kriaucionis aims to to elucidate the molecular function of DNA modifications in normal cells and cancer.
Although all cells in our body have the same genome, they look different and perform different functions. Epigenetic modifications such as methylations ensure which sets of genes are expressed in specific cells and how this specificity is inherited. Cancer cells show particular epigenetic abnormalities which can be targeted for cancer therapies.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Cancer
People
Skirmantas Kriaucionis
Keywords
cancer
Epigenetics
DNA
molecules
cells
genome
Department: Nuffield Department of Clinical Medicine
Date Added: 14/12/2016
Duration: 00:05:44

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Fighting malaria in Myanmar

Series
Global Health
Embed
Professor Frank Smithuis is the director of MOCRU, Myanmar Oxford Clinical Research Unit. MOCRU involves a network of 6 clinics and 650 community health workers in remote areas.
Up until now, Myanmar has spent little on heathcare and receive little assistance from rich countries. Prevention is difficult, which leaves diagnosis and treatment. MOCRU has set up a network of community health workers, trained and supplied with diagnostics and treatments, to help improve access to healthcare for remote communities.
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Global Health
People
Frank Smithuis
Keywords
malaria
myanmar
clinical research
community health
diagnosis
treatment
Department: Nuffield Department of Clinical Medicine
Date Added: 14/12/2016
Duration: 00:06:44

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What would life be like if Parasitoid Wasps didn’t exist?

Series
Big Questions - with Oxford Sparks
Embed
Our Festive episode of our Oxford Sparks podcast follows the traditional Christmas story of ‘It’s a Wonderful Life’.
In our narration though, the role of George Bailey is played by the Parasitoid Wasp and its guardian angel is postdoctoral researcher Chris Jeffs. In this podcast as part of our Big Questions series, we ask the question: what would life be like if these insects didn’t exist?

Episode Information

Series
Big Questions - with Oxford Sparks
People
Christopher Jeffs
Keywords
wasps
science
zoology
insects
ParasitoidWasp
podcast
OxfordUniversity
OxfordSparks
BigQuestions
discovery
oxford
christmas
itsawonderfullife
Department: Mathematical, Physical and Life Sciences (MPLS)
Date Added: 14/12/2016
Duration: 00:13:08

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Staging History: favourite objects and concluding thoughts

Series
Staging History, 1780 to 1840
Embed
The series concludes with each of the contributors discussing an object that particularly stands out for them from the exhibition items and what it reveals about staging history in this period.
The contributors finish by offering some concluding thoughts about the overall findings of the ‘Staging History’ project.

Episode Information

Series
Staging History, 1780 to 1840
People
Michael Burden
David Kennerley
Susan Valladares
Keywords
theatre
objects
exhibition
history
Department: Bodleian Libraries
Date Added: 14/12/2016
Duration: 00:09:44

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History on stage

Series
Staging History, 1780 to 1840
Embed
In this episode, the contributors discuss why history so frequently featured on stage in this period, and the significance of the historical events that these dramas staged for contemporary audiences.
Various examples of history on stage are discussed, ranging from the siege of Gibraltar to Rip van Winkle’s American adventures, and from the conquest of Peru to the Napoleonic wars. The episode concludes with a discussion of the pre-eminent historical fiction author Walter Scott, and the enormous influence of his works on Regency theatre and opera.

Episode Information

Series
Staging History, 1780 to 1840
People
Michael Burden
David Kennerley
Susan Valladares
Keywords
history
Georgian
theatre
Walter Scott
Department: Bodleian Libraries
Date Added: 14/12/2016
Duration: 00:18:25

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Experiencing the late Georgian theatre

Series
Staging History, 1780 to 1840
Embed
This episode explores what it was like to experience theatre in this era, including how theatres were laid out and designed, what it was like to be in the audience, and how plays were written, advertised and staged.
The contributors also discuss the impact of new technologies, like gas lighting, and exciting spectacles, such as elephants, grand processions, and on-stage naval battles in a tank of real water.

Episode Information

Series
Staging History, 1780 to 1840
People
Michael Burden
David Kennerley
Susan Valladares
Keywords
theatre
Georgian
staging
drama
audiences
Department: Bodleian Libraries
Date Added: 14/12/2016
Duration: 00:16:45

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