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Tuberculous Meningitis

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Translational Medicine
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Tuberculous Meningitis
Professor Guy Thwaites is trying to improve outcomes for patients with tuberculous meningitis, the most severe form of tuberculosis. 100, 000 people a year get tuberculous meningitis and without treatment 100% of people with the disease will die.
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Series
Translational Medicine
People
Guy Thwaites
Keywords
guy thwaites
tuberculous meningitis
Department: Nuffield Department of Clinical Medicine
Date Added: 07/10/2014
Duration: 07:49:00

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Crohn's disease

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Translational Medicine
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Innate immune system
Professor Alison Simmons is interested in the molecular aspects of innate immune recognition, the primitive arm of the immune system that defends the host from infection by other organisms in a non-specific manner. Defects in the innate immune system can result in difficulty clearing infections but also in inflammation.
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Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Translational Medicine
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Alison Simmons
Keywords
alison simmons
crohns's disease
innate immunity
Department: Nuffield Department of Clinical Medicine
Date Added: 07/10/2014
Duration: 07:09:00

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Structural biology and vaccines

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Translational Medicine
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Structure of viruses
Professor David Stuart studies the structure of viruses at the molecular level. His work is particularly interested in virus-receptor interaction and the basic puzzles of virus assembly and he uses structural biology to answer these questions.

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Series
Translational Medicine
People
Dave Stuart
Keywords
dave stuart
structural biology
viruses
molecular
Department: Nuffield Department of Clinical Medicine
Date Added: 07/10/2014
Duration: 00:07:56

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Stem cells and cancer

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Translational Medicine
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Adult gastrointestinal stem cells
The gastrointestinal tract is lined with a single sheet of epithelium that is replaced every 4-5 days. The base of a flask-shaped structured called the crypt is where the gastrointestinal stem cells are found. These divide to form daughter cells that travel up the crypt to replace these cells. Dr Simon Leedham's current research focuses on the cell-signaling pathways that control intestinal stem cells and the dysregulation of these pathways in cancer.
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Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Series
Translational Medicine
People
Simon Leedham
Keywords
simon leedham
cancer
stem cells
gastrointestinal
Department: Nuffield Department of Clinical Medicine
Date Added: 07/10/2014
Duration: 05:18:00

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Cancer and innate immunity

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Translational Medicine
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Inflammatory signalling
Dr Mads Gyrd-Hansen aims to elucidate fundamental mechanisms governing pro-inflammatory signalling during innate immune responses, and through this, to better understand how aberrant inflammatory signalling contributes to tumour development and cancer progression.
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Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Translational Medicine
People
Mads Gryd-Hansen
Keywords
mads gryd-hansen
cancer
innate immunity
tumour
Department: Nuffield Department of Clinical Medicine
Date Added: 07/10/2014
Duration: 05:57:00

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Asthma

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Translational Medicine
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Airway inflammation
Ian Pavord is Professor of Respiratory Medicine and has been joint Chief Medical Advisor to Asthma UK since May 2008. He has developed new techniques to get a better idea about airway inflammation and uses this information to investigate the best treatments to prevent asthma attacks.

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Series
Translational Medicine
People
Ian Pavord
Keywords
ian pavord
respiratory medicine
asthma
Department: Nuffield Department of Clinical Medicine
Date Added: 07/10/2014
Duration: 07:05:00

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Pneumococcal diseases

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Translational Medicine
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Genetics and genomics of Streptococcus pneumoniae
Angela Brueggemann's main focus is using high-throughput genotyping and whole genome sequencing techniques and unique collections of isolates to understand pneumococcal evolution, especially evolutionary changes related to antimicrobial and vaccine selective pressures.
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Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Translational Medicine
People
Angela Brueggemann
Keywords
angela brueggemann
streptococcus pneumoniae
pneumococcal
Department: Nuffield Department of Clinical Medicine
Date Added: 07/10/2014
Duration: 04:59:00

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Helen McShane: Women in science

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Women in Medical Science
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A career in juggling, organisation and guilt management
Professor Helen McShane has been working on a new TB vaccine for 10 years. There are about 9 million new cases and 1.7 million deaths every year from tuberculosis. She developed MVA85A, a vaccine with the aim to boost the cellular immune response induced by BCG. Developing countries are especially in need of a new vaccine since HIV and TB epidemics overlap and show a devastating synergy.

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Series
Women in Medical Science
People
Helen McShane
Keywords
helen mcshane
women in science
tuberculosis
Department: Nuffield Department of Clinical Medicine
Date Added: 07/10/2014
Duration: 00:23:03

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Health systems research

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Crossing Boundaries
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Governance in practice
Dr Sassy Molyneux's main interests reside in Social science and Ethics in Public Health. Over the years, social scientists have developed a programme of empirical work on research ethics. This work is based on an understanding that while the ethics of human subjects research may be universal, there can be big differences across contexts and circumstances in key ethical issues or principles.
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Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Crossing Boundaries
People
Sassy Molyneux
Keywords
sassy molyneux
health systems research
Department: Nuffield Department of Clinical Medicine
Date Added: 07/10/2014
Duration: 07:11:00

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Better hospitals for children

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Crossing Boundaries
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Oxford Health Systems Research Collaboration (OHSCAR)
Professor Mike English leads the Health Services Unit at the KEMRI-Wellcome Trust Research Programme in Nairobi, Kenya. This unit aims to strengthen equality in access to affordable quality health care in Africa. Studies are based on health systems clustered around five main topics: malaria, service delivery & access, information for decision making, governance and financing.

Professor English leads efforts to develop multidisciplinary links with Oxford through the Oxford Health Systems Research Collaboration (OHSCAR).
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Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Crossing Boundaries
People
Mike English
Keywords
mike english
hospitals
children
health systems research
Department: Nuffield Department of Clinical Medicine
Date Added: 07/10/2014
Duration: 04:23:00

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