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St Cross Seminar: The role of therapeutic optimism in recruitment to a clinical trial: an empirical study

Series
Uehiro Oxford Institute
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In this St Cross Special Ethics Seminar, Dr Nina Hallowell discusses the importance of therapeutic optimism in clinical research.
Hope, or therapeutic optimism, is an important aspect of the provision and experience of medical care. The role of therapeutic optimism in clinical research has been briefly discussed within the empirical and bioethics literature, but the concept, and whether it can be transferred from care to research and from patients to clinicians, has not been fully investigated. Interviews with clinical staff involved in a peripartum randomised placebo-controlled trial– the Got-it trial - revealed that therapeutic optimism has an important role to play facilitating clinical staff engagement with trial work. In this paper I will unpack the concept of therapeutic optimism in trial settings, describe how it is sustained in practice and outline some of the ethical risks and benefits.

Episode Information

Series
Uehiro Oxford Institute
People
Nina Hallowell
Keywords
clinical trials
clinical research
ethics
therapeutic optimism
Department: Uehiro Oxford Institute
Date Added: 16/05/2016
Duration: 00:49:06

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How Judges Decide

Series
Foundation for Law, Justice and Society
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Justice Robert J Sharpe of the Ontario Court of Appeal and Visiting Professor, University of Oxford, gives a talk for the FLJS seminar series.
Examining the twin phenomena of legal uncertainty and laws that sometimes produce unjust results, Justice Robert J Sharpe of the Ontario Court of Appeal concluded that both arose from an essential characteristic of the law itself, in which it had to be framed in terms of norms or standards with general application.

In his FLJS lecture ‘How Judges Decide’, Justice Sharpe said that while laws set standards, they didn’t decide specific cases, and this was where judges must use their skills, expertise, and exercise judgement. ‘That is the role of the judge: to interpret the standard and decide whether or not it applies to the facts of the case,’ he said.

Justice Sharpe argued that the law should be examined in both context and legal formulation, stating that, as a judge, he saw the law as a tool, rather than an abstraction, and that the proper interpretation and application of legal rules depended upon the context.

That context itself could change as social conditions and attitudes evolved. He cited the example of equality in law and same sex relationships. Once criminalized, same sex relationships now enjoy legal protection, as the meaning of equality, as a cornerstone of the rule of law, had changed alongside social attitudes.

This did not, argued Justice Sharpe, mean that law subject to context was uncertain or wide open to individual judges’ perceptions, beliefs and biases.

He accepted that legal reasoning had a formal structure to which judges must adhere but said that the law did not operate in a vacuum and that he often had to decide on legal disputes that arose from the realities of daily life and a wide range of changing social, economic and political contexts.

It would, he said, be impossible to apply the law in a mechanical way. This would be to ignore the important question of what values actually drive and determine decisions.

Judicial reasoning, reflecting upon and questioning the values that they apply was essential for all judges, he said.

Justice Sharpe then examined the two, disparate schools of thought, where, on the one hand, narrow legalism meant always deciding according to the letter of the law and, on the other, the uncertainty of its meaning and context rendered the law indeterminate.

He then put the question of judicial decision-making into perspective, where, he said, the majority of legal cases centred around contested issues of fact, not law. Focusing on the few difficult appellate decisions was to ignore the vast majority of readily resolved disputes.

The majority of his work as an intermediate appellate court judge was, said Justice Sharpe, ‘error correction’ and we should not become too obsessed with hard cases, where uncertainty reigns.

‘Our encounters with trees - the tough cases - may have caused us to lose sight of the forest - the law,’ he said.

Moving on to difficult cases where the law doesn’t not have a clear answer, Justice Sharpe argued that it was not his personal beliefs and values that determined the case.

‘It seems to me that correct results are what the legal system aspires to achieve and that my working hypothesis has to be that I am in pursuit of the right answer...’

While rejecting narrow legalism, Justice Sharpe accepted that there was a necessary element of formalism in judicial decision-making, such as minimum statutory mandatory sentences, and stare decisis, the legal principle of determining points in litigation according to precedent.

He then described the ‘artificial reason’ of the law, where arguments must have a certain pedigree to qualify as legitimate, and discussed collegial decision-making, which provided a strong counter-weight to any arguments that judges are influenced by values extraneous to the law and would, certainly, dilute any personal views.

The collegial process also meant judges must listen to and engage with arguments by both the litigants and lawyers and those of fellow judges, when preparing reasons for a particular judgment.

Judicial authority was equally constrained by the need to respect the boundaries of decision-making authority, as well as the evidence, record and the parameters of the dispute.

While accepting that legal scholars and many judges and lawyers doubted the efficacy of these described constraints, Justice Sharpe also touched on the discipline of reasons, where the obligation to give reasons for a particular decision was far more than just a legal formality.

For litigants, reasons were more than just a simple matter of justice and fairness, he said. They represented the right to be heard.

A reasoned decision helps a losing litigant know that the judge actually understood and grappled with the issues. It needs to be completely clear to both parties why one has lost and the other has won.

‘Reasons,’ argued Justice Sharpe, ‘demonstrate that the decision was not arbitrary or based on personal whim.

‘Reasons reflect our obligation to expose our thinking to the parties, the appeal process, the academics, the media, the public, and the politicians.

‘If our reasons are not based upon sources and arguments accepted by the legal community or fail to abide by the relevant accepted legal norms, they will not withstand scrutiny, whether in the court of appeal or in the court of public opinion.’

Episode Information

Series
Foundation for Law, Justice and Society
People
Robert J Sharpe
Keywords
law
society
justice
judges
legal
canada
Department: Centre for Socio-Legal Studies
Date Added: 16/05/2016
Duration: 00:41:26

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What We Cannot Know - Marcus du Sautoy

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The Secrets of Mathematics
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Science is giving us unprecedented insight into the big questions that have challenged humanity.

Where did we come from? What is the ultimate destiny of the universe? What are the building blocks of the physical world? What is consciousness?

'What We Cannot Know' asks us to rein in this unbridled enthusiasm for the power of science. Are there limits to what we can discover about our physical universe? Are some regions of the future beyond the predictive powers of science and mathematics? Are there ideas so complex that they are beyond the conception of our finite human brains? Can brains even investigate themselves or does the analysis enter an infinite loop from which it is impossible to rescue itself?

To coincide with the launch of his new book of the same title, Marcus du Sautoy will be answering (or not answering) those questions

Episode Information

Series
The Secrets of Mathematics
People
Marcus du Sautoy
Keywords
maths
Department: Mathematical Institute
Date Added: 16/05/2016
Duration:

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Oral History Collections

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Exploring Spoken Word Data in Oral History Archives
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How to exploit the multidisciplinary potential of Oral History narratives
Presentation from Stef Scagliola of Erasmus University Rotterdam at the event "Exploring Spoken Word Data in Oral History Archives", held at the e-Research Centre, University of Oxford, on 18-19 April 2016, organized by Martin Wynne as part of the CLARIN-PLUS project (http://www.clarin.eu).

Elicited personal spoken narratives have a physical dimension - pressure waves traveling through the air between two speakers - and a semantic dimension - memories and self representations that are woven into a co-created story. The story can be suited for scholarly use or reuse and for a variety of purposes. It may contain references to facts that are omitted from written sources, it can shed light on coping mechanisms to overcome adversity, but it can also offer insights in the structure of dialogue, the relation between vocal and facial expression and gender-related aspects of language use.

Progress in digital technology has transformed the oral history landscape. Before the ‘digital revolution’, the only viable way to access and analyse this type of data was through its textual representation: printed catalogues and transcripts. Nowadays, a considerable number of the vast array of oral history collections that have been created worldwide since the introduction of cheap recording technology in the 1960’s, is available online. Individual researchers are increasingly encouraged to deposit their interviews after completion of their research, so that other scholars can reuse them. This has yielded a huge potential of useful data for multiple academic audiences.

The question is how digital tools created to support humanities research in general, can be tailored to extract the characteristic features of personal narratives in ways that match specific methodologies of diverse disciplines. In other words, how can innovation in computer science support the exploitation of this multilayered type of data and bring about innovation in cross-disciplinary scholarly research? Search technology has provided new frameworks that facilitates interaction with the data at various semantic levels. Progress can also be observed with regard to manual annotation tools. But when it comes to the next stage of the research process, the analysis of data, the bottle neck for wide-scale reuse of oral history remains the lack of transcripts, because of the dependency on the labour-intensive process of manual transcription. How to set the agenda for collaboration between developers and the various scholarly communities that want to use oral history material as research data?
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Exploring Spoken Word Data in Oral History Archives
People
Stef Scagliola
Keywords
oral history
Department: Oxford e-Research Centre
Date Added: 16/05/2016
Duration: 00:31:45

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Oral History as Research Data

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Exploring Spoken Word Data in Oral History Archives
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Interviews, collections, archives, data and history - a view from the UK Data Archive.
Louise Corti from the UK Data Archive, at the event "Exploring Spoken Word Data in Oral History Archives", held at the e-Research Centre, University of Oxford on 18-19 April 2016, organized by Martin Wynne as part of the CLARIN-PLUS project (http://www.clarin.eu).
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Exploring Spoken Word Data in Oral History Archives
People
Louise Corti
Keywords
oral history
Department: Oxford e-Research Centre
Date Added: 16/05/2016
Duration: 00:26:03

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From Search to Exploration

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Exploring Spoken Word Data in Oral History Archives
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Barriers and opportunities in using oral history archives as data resources
Opening keynote presentation from Jakub Mlynář from the Centre for Visual History Malach in Prague at the event "Exploring Spoken Word Data in Oral History Archives", held at the e-Research Centre, University of Oxford on 18-19 April 2016, organized by Martin Wynne as part of the CLARIN-PLUS project (http://www.clarin.eu).
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Exploring Spoken Word Data in Oral History Archives
People
Jakub Mlynář
Keywords
oral history
CLARIN
holocaust
refugees
forced migration
Department: Oxford e-Research Centre
Date Added: 16/05/2016
Duration: 00:34:02

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'Poland: Internationalism, Nationalism and Challenges of the International Environment'

Series
Politics and International Relations Podcasts
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President of the Stefan Batory Foundation Aleksander Smolar discusses nationalism and internationalism in contemporary Poland
Creative Commons Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK (BY-NC-SA): England & Wales; https://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Politics and International Relations Podcasts
People
Aleksander Smolar
Stephen Whitefield
Keywords
poland
nationalism
international relations
solidarity
Social Movements
Department: Department of Politics and International Relations (DPIR)
Date Added: 16/05/2016
Duration: 00:41:38

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Medieval Song

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In Our Spare Times
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Oxford students discuss medieval songs.
The thirteenth century was a time of great change in Europe. The cities of Florence, Paris and Arras became thriving commercial centres; following the disastrous reign of King John of England, the French crown had also grown significantly in strength. Into this world we find the trouvères, poets and musicians who wrote and sang about the pains of love, on politics, and of devotion to the Virgin Mary. Their songs, preserved in twenty song-compendia called Chansonniers, but also found scattered throughout many early medieval manuscripts, are a rare window into medieval vernacular culture.
Host: Aled Walker (2nd year DPhil student, Mathematics, Magdalen College). Contributors: Meghan Quinlan (2nd year DPhil student, Musicology, Merton College), Joseph Mason (2nd year DPhil Student, Musicology, Lincoln College). ​

Episode Information

Series
In Our Spare Times
People
Aled Walker
Meghan Quinlan
Joseph Mason
Keywords
history
song
medieval
music
musical studies
Department: Magdalen College
Date Added: 13/05/2016
Duration: 00:44:16

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Donne to Death

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The Bodleian Libraries (BODcasts)
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Peter McCullough, Professor of English, University of Oxford, gives a talk on John Donne.
John Donne's sermon, Death's duell, was part of an early Stuart vogue for funeral sermons. Professor McCullough discusses Donne's contribution to this genre, and looks at how this tradition is connected to the poetic and dramatic representations of death on display in the exhibition, Shakespeare's Dead.

Episode Information

Series
The Bodleian Libraries (BODcasts)
People
Peter McCullough
Keywords
john donne
poetry
literature
death
Department: Bodleian Libraries
Date Added: 13/05/2016
Duration: 00:43:07

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'Learning' part 2 - Stimulating learning

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Big Questions - with Oxford Sparks
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Can a little electrical stimulation help people learn quicker? And how would technology that does this be used? And why would you want to use this over medicines?
Professor Roi Cohen Kadosh describes a phenomena that they've noticed where giving people a little electrical stimulation to the scalp appears to help people learn things quicker; and rather than using this to make super-geniuses, could this be used to help people with learning difficulties? Roi discusses how it might work, and discussed the moral and ethical implications of such a technology.

Episode Information

Series
Big Questions - with Oxford Sparks
People
Roi Cohen Kadosh
Keywords
biology
psychology
neuroscience
cognitive science
learning
electricity
Medicine
learning difficulties
technology
education
Department: Mathematical, Physical and Life Sciences (MPLS)
Date Added: 13/05/2016
Duration: 00:11:52

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