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Nuffield Department of Clinical Medicine

The Nuffield Department of Medicine (NDM) is a large multi-disciplinary Department that links high quality basic biological science with medical application. Led by Professor Peter Ratcliffe FRS, who is both an active researcher in cell biology and an active clinician, the Department employs in the region of 1000 scientific research staff working in a range of basic science and clinical disciplines. Our researchers contribute to the teaching of 450 medical students within Oxford University's Clinical School.
Our base at the Headington Hospitals campus, Oxford, is now one of the largest centres for biomedical research in Europe with over £200M invested in capital projects and research infrastructure over the last decade. The rapidly growing campus provides a vibrant, highly interactive environment for research development. We are particularly committed to the career development of young scientists, including those from basic science as well as clinical backgrounds. In 2006 the Oxford University / Oxford Radcliffe Hospital Trust partnership successfully competed to be one of five UK Biomedical Research Centres. We played a leading role in this initiative, which provides a range of new opportunities for basic scientists to interact with clinical medical research, and for career development of clinician scientists.
In addition to its Oxford base, the Department operates a number of major overseas programmes in tropical medicine and global health, with research units in Thailand, Laos, Vietnam and Kenya supporting activities at numerous sites in S-E Asia and Sub-Saharan Africa. We also operate extensive epidemiological and clinical trials networks throughout China, India and South America.
In Oxford, NDM maintains research platforms across structural biology, protein biochemistry, genetics, genomics, proteomics, cell biology, chemical and genetic screening, imaging, bioinformatics, medical statistics, epidemiology, and clinical trials. Thematic research includes cancer biology, immunology, vaccinology, infectious diseases, gastroenterology, dermatology, diabetes and metabolic medicine, renal medicine, respiratory medicine, stroke medicine, and geratology.

Series associated with Nuffield Department of Clinical Medicine

Africa Oxford Initiative
Autoimmune Disease
Cancer
Career Equality Talks
Centre for Personalised Medicine
Crossing Boundaries
Diabetes and Obesity
Epidemics and Vaccines
Families for the Treatment of Hereditary Motor Neuron Disease
Genetics
Global Health
HIV
Immunology
Inspiring Women in Science
Malaria
McMichael Symposium
NDM International Activities
NDM Public Engagement
NDM Units
Nuffield Department of Medicine, Meet our Students
Revolutionary Biology
Translational and Clinical
Translational Medicine
Wellcome Trust Centre for Human Genetics
Women in Medical Science
# Episode Title Description People Date
101 Method in the Motion A unique evening combining a scientific talk with inspirational dance. Irina Pulyakhina, Flux 14 Jul 2016
102 Creative Commons Modelling bacterial drug resistance Professor Ben Cooper from MORU in Thailand uses mathematical modelling and statistical techniques to help understand the dynamics of infectious disease and evaluate potential control measures. Ben Cooper 01 Jul 2016
103 Creative Commons Epidemiology and malaria elimination Dr Richard Maude's work combines clinical studies, descriptive epidemiology and mathematical modelling of malaria in South and Southeast Asia. Richard Maude 01 Jul 2016
104 Creative Commons Modelling bacterial drug resistance Professor Ben Cooper from MORU in Thailand uses mathematical modelling and statistical techniques to help understand the dynamics of infectious disease and evaluate potential control measures. Ben Cooper 01 Jul 2016
105 Creative Commons Epidemiology and malaria elimination Dr Richard Maude's work combines clinical studies, descriptive epidemiology and mathematical modelling of malaria in South and Southeast Asia. Richard Maude 01 Jul 2016
106 Creative Commons Why data management matters Naomi’s work focuses on supporting researchers to collect, clean and store research data. Naomi Waithira 02 Jun 2016
107 Creative Commons Malaria laboratory at MORU Dr Kesinee Chotivanich's laboratory provides facilities and resources to researchers, students, and collaborators who are interested in tropical diseases, with the aim to improve patients’ care. Kesinee Chotivanich 02 Jun 2016
108 Creative Commons From information to structure Dr Brian Marsden aims to make structural and chemical biology data accessible to non-experts, by providing computational resources including data management, sample tracking, in silico modelling support plus provision of public access to SGC data. Brian Marsden 02 Jun 2016
109 Creative Commons Why data management matters Naomi’s work focuses on supporting researchers to collect, clean and store research data. Naomi Waithira 02 Jun 2016
110 Creative Commons Malaria laboratory at MORU Dr Kesinee Chotivanich's laboratory provides facilities and resources to researchers, students, and collaborators who are interested in tropical diseases, with the aim to improve patients’ care. Kesinee Chotivanich 02 Jun 2016
111 Creative Commons From information to structure Dr Brian Marsden aims to make structural and chemical biology data accessible to non-experts, by providing computational resources including data management, sample tracking, in silico modelling support plus provision of public access to SGC data. Brian Marsden 02 Jun 2016
112 Creative Commons Repairing DNA damage Dr Ross Chapman studies the molecular events triggered by DNA damage detection, and why defects in these events lead to immune deficiency and cancer in humans. Ross Chapman 28 Apr 2016
113 Creative Commons Malaria in Kenya There is a great need for better treatments for malaria and for a preventative malaria vaccine. Philip Bejon 28 Apr 2016
114 Creative Commons Microbiology in the tropics The Cambodia Oxford Medical Research Unit (COMRU) is based in Siem Reap, northern Cambodia, which remains one of the poorest countries in South East Asia with extremely limited health services. Paul Turner 28 Apr 2016
115 Unravelling proteins Dr Nicola Burgess-Brown heads the Biotechnology Group at the SGC, which generates proteins suitable for structural and functional studies. Nicola Burgess-Brown 28 Apr 2016
116 Targeting drug discovery The development of new medicines is dependent on the identification of novel drug targets. Kilian Huber 28 Apr 2016
117 Creative Commons Microbiology research in SE Asia Dr Direk Limmathurotsakul's research focuses on the epidemiology of melioidosis, a bacterial infection caused by Burkholderia pseudomallei. Direk Limmathurotsakul 28 Apr 2016
118 Creative Commons Tropical neonatology Dr Claudia Turner heads the clinical research program at the Cambodia Oxford Medical Research Unit (COMRU), in collaboration with the Angkor Hospital for Children. Claudia Turner 28 Apr 2016
119 Creative Commons Global health informatics Dr Chris Paton studies the use of open-source Electronic Health Records (EHR) software, online learning and mobile technology to improve healthcare delivery in low-resource settings. Chris Paton 28 Apr 2016
120 Creative Commons Dengue diagnosis and management With 390 million infections occuring each year, dengue is the most important mosquito-borne viral infection, and no vaccine is currently available. Bridget Wills 28 Apr 2016
121 Understanding growth signals Growth hormones and cytokines regulate the key physiological processes of growth and differentiation as well as responses to injury and infection. Alex Bullock 28 Apr 2016
122 Creative Commons Repairing DNA damage Dr Ross Chapman studies the molecular events triggered by DNA damage detection, and why defects in these events lead to immune deficiency and cancer in humans. Ross Chapman 28 Apr 2016
123 Creative Commons Malaria in Kenya There is a great need for better treatments for malaria and for a preventative malaria vaccine. Philip Bejon 28 Apr 2016
124 Creative Commons Microbiology in the tropics The Cambodia Oxford Medical Research Unit (COMRU) is based in Siem Reap, northern Cambodia, which remains one of the poorest countries in South East Asia with extremely limited health services. Paul Turner 28 Apr 2016
125 Creative Commons Unravelling proteins Dr Nicola Burgess-Brown heads the Biotechnology Group at the SGC, which generates proteins suitable for structural and functional studies. Nicola Burgess-Brown 28 Apr 2016
126 Creative Commons Targeting drug discovery The development of new medicines is dependent on the identification of novel drug targets. Kilian Huber 28 Apr 2016
127 X-rays for drug discovery Dr Frank von Delft works to ensure that X-ray structures can serve as a routine and predictive tool for generating novel chemistry for targeting proteins. Frank von Delft 28 Apr 2016
128 Creative Commons Microbiology research in SE Asia Dr Direk Limmathurotsakul's research focuses on the epidemiology of melioidosis, a bacterial infection caused by Burkholderia pseudomallei. Direk Limmathurotsakul 28 Apr 2016
129 Creative Commons Tropical neonatology Dr Claudia Turner heads the clinical research program at the Cambodia Oxford Medical Research Unit (COMRU), in collaboration with the Angkor Hospital for Children. Claudia Turner 27 Apr 2016
130 Creative Commons Global health informatics Dr Chris Paton studies the use of open-source Electronic Health Records (EHR) software, online learning and mobile technology to improve healthcare delivery in low-resource settings. Chris Paton 27 Apr 2016
131 Creative Commons Dengue diagnosis and management With 390 million infections occuring each year, dengue is the most important mosquito-borne viral infection, and no vaccine is currently available. Bridget Wills 27 Apr 2016
132 Creative Commons Understanding growth signals Growth hormones and cytokines regulate the key physiological processes of growth and differentiation as well as responses to injury and infection. Alex Bullock 27 Apr 2016
133 Variation across the human genome: a tricky balancing act in human health and disease Genetic variation can have opposing effects on human disease, where the benefits of a protective variant against one disease can increase the risk of another. Mary Carrington 10 Feb 2016
134 Malaria in pregnancy In pregnant women, severe malaria is responsible for high maternal mortality, and uncomplicated malaria results in in high morbidity. Rose McGready 04 Feb 2016
135 Reducing HIV Men who have sex with men (MSM) are a stigmatised group in Africa, but a predominant actor in the transmission of HIV. Eduard Sanders 04 Feb 2016
136 Creative Commons Cleaning up misfolded proteins Misfolded proteins can either create the loss of a cellular function, or escape degradation, causing aggregation diseases. John Christianson 04 Feb 2016
137 Creative Commons Rare neurological disorders Chorea-Acanthocytosis: ChAc is a rare progressive neurological disorder caused by mutations in a very complex gene. Antonio Velayos-Baeza 04 Feb 2016
138 Creative Commons Malaria in pregnancy In pregnant women, severe malaria is responsible for high maternal mortality, and uncomplicated malaria results in in high morbidity. Rose McGready 04 Feb 2016
139 Creative Commons Reducing HIV Men who have sex with men (MSM) are a stigmatised group in Africa, but a predominant actor in the transmission of HIV. Eduard Sanders 04 Feb 2016
140 Creative Commons Cleaning up misfolded proteins Misfolded proteins can either create the loss of a cellular function, or escape degradation, causing aggregation diseases. John Christianson 04 Feb 2016
141 Creative Commons Rare neurological disorders Chorea-Acanthocytosis: ChAc is a rare progressive neurological disorder caused by mutations in a very complex gene. Antonio Velayos-Baeza 04 Feb 2016
142 Creative Commons Targeting cancer mechanisms Professor Robert Gilbert's research focuses on the molecular mechanisms underlying membrane pore formation and cell adhesion. Robert Gilbert 07 Jan 2016
143 Inflammation in disease The main aim of Dr Xue's research is to understand the molecular and cellular mechanisms mediating inflammatory diseases, and to translate their findings into therapeutic concepts to treat these diseases. Luzheng Xue 07 Jan 2016
144 Creative Commons Computation and genetics Resistance to drugs in bacteria can be aquired by swapping genes between individual bacteria. Computer programs developed by Dr Iqbal enable doctors to predict which antibiotics will be met with drug resistance, enabling the selection of the right drug. Zamin Iqbal 07 Jan 2016
145 Creative Commons Targeting cancer mechanisms Professor Robert Gilbert's research focuses on the molecular mechanisms underlying membrane pore formation and cell adhesion. Robert Gilbert 07 Jan 2016
146 Creative Commons Inflammation in disease The main aim of Dr Xue's research is to understand the molecular and cellular mechanisms mediating inflammatory diseases, and to translate their findings into therapeutic concepts to treat these diseases. Luzheng Xue 07 Jan 2016
147 Creative Commons Computation and genetics Resistance to drugs in bacteria can be aquired by swapping genes between individual bacteria. Computer programs developed by Dr Iqbal enable doctors to predict which antibiotics will be met with drug resistance, enabling the selection of the right drug. Zamin Iqbal 07 Jan 2016
148 NDM Studentships Every year, about 60 DPhil students start a life changing experience in the Nuffield Department of Medicine at the University of Oxford. Robert Gilbert, Steinar Halldorsson, Sophie Andrews 02 Dec 2015
149 Creative Commons The Evolution of the Genome Computational and stastistical methods help us understand evolution as well as genetic disease. Gerton Lunter 02 Dec 2015
150 Tropical Immunology Melioidosis is a neglected tropical disease, and a major infectious killer in South East Asia. Melioidosis particularly affects people with diabetes. Susanna Dunachie 02 Dec 2015
151 Sharing data to fight malaria Over 250 Institutions participate in the effort of sharing data on the efficacy of antimalarial drugs, which involves standardising and re-analysing data. Philippe Guérin 02 Dec 2015
152 Creative Commons The Evolution of the Genome Computational and stastistical methods help us understand evolution as well as genetic disease. Gerton Lunter 02 Dec 2015
153 Creative Commons Tropical Immunology Melioidosis is a neglected tropical disease, and a major infectious killer in South East Asia. Melioidosis particularly affects people with diabetes. Susanna Dunachie 02 Dec 2015
154 Creative Commons Sharing data to fight malaria Over 250 Institutions participate in the effort of sharing data on the efficacy of antimalarial drugs, which involves standardising and re-analysing data. Philippe Guérin 02 Dec 2015
155 Science in a crisis, fast-forwarding clinical research for Ebola Professor Peter Horby's research focuses on epidemic diseases such as Ebola and bird flu, and crosses the disciplines of basic science, medical science and public health. Peter Horby 02 Dec 2015
156 Steinar Halldorsson Every year, about 60 DPhil students start a life changing experience in the Nuffield Department of Medicine in Oxford. Steinar Halldorsson 02 Dec 2015
157 Sophie Andrews Every year, about 60 DPhil students start a life changing experience in the Nuffield Department of Medicine in Oxford. Sophie Andrews 02 Dec 2015
158 Creative Commons The Heart and the Head, Part 5 Daniel Bulte, from the Department of Oncology, speaks about what happens when they discover an ‘incidental finding’. Daniel Bulte 16 Nov 2015
159 Creative Commons The Heart and the Head, Part 4 Portia Westall, from the Donnelly group at the WTCHG, speaks about how she thinks about music when working on DNA sequences. Portia Westall 16 Nov 2015
160 Creative Commons The Heart and the Head, Part 3 Erwan Atcheson, from the Jenner Institute, speaks about his time studying parasitic worms, and the worries that come with it. Erwan Atcheson 16 Nov 2015
161 Creative Commons The Heart and the Head, Part 2 Anna Fowler, from the Lunter group at the WTCHG, speaks about how the patterns around a close-call in the desert makes her think about her work. Anna Fowler 16 Nov 2015
162 Creative Commons The Heart and the Head, Part 1 Irina Pulyakhina, from the Julian Knight group at the WTCHG, speaks about her time helping a Masters student through an important presentation. Irina Pulyakhina 16 Nov 2015
163 Creative Commons The Heart and the Head, the full evening of science, storytelling, and music An evening of storytelling and music where researchers from the Wellcome Trust Centre for Human Genetics, the Jenner Institute, and Cancer Research UK came together to tell stories about their lives as scientists, with live musical accompaniment. Erwan Atcheson, Daniel Bulte, Anna Fowler, Brian Mackenwells 16 Nov 2015
164 Creative Commons Artemisinin Resistance Artemisinins are very poweful tools in the treatment of malaria, and the emerging loss of their activity has the potential to create a major public health problem. Charlie Woodrow 05 Oct 2015
165 Creative Commons The ethics of research Identifying and addressing ethical issues are key to the success of any clinical trials, particularly when working with vulnerable populations. Phaik Yeong Cheah 05 Oct 2015
166 Creative Commons Science and Society In settings with high level of poverty and over-stretched health services, researchers have even greater responsibilities to the communities and study participants. Vicki Marsh 05 Oct 2015
167 Creative Commons Melanoma Melanoma or skin cancer is one of the fastest rising cancer types. When identified early, melanoma is relatively easy to cure, but once it starts to metastasise, it becomes very difficult to treat. Colin Goding 05 Oct 2015
168 Creative Commons Targeting epigenetics to treat cancer Transcription is a tightly regulated process, where chemical modifications initiate the duplication of genetic material. This epigenetic process is often dysregulated in cancer, but it can be targeted with small molecule inhibitors. Panagis Filippakopoulos 05 Oct 2015
169 Creative Commons Artemisinin Resistance Artemisinins are very poweful tools in the treatment of malaria, and the emerging loss of their activity has the potential to create a major public health problem. Charlie Woodrow 05 Oct 2015
170 Creative Commons The ethics of research Identifying and addressing ethical issues are key to the success of any clinical trials, particularly when working with vulnerable populations. Phaik Yeong Cheah 05 Oct 2015
171 Creative Commons Science and Society In settings with high level of poverty and over-stretched health services, researchers have even greater responsibilities to the communities and study participants. Vicki Marsh 05 Oct 2015
172 Creative Commons Melanoma Melanoma or skin cancer is one of the fastest rising cancer types. When identified early, melanoma is relatively easy to cure, but once it starts to metastasise, it becomes very difficult to treat. Colin Goding 05 Oct 2015
173 Creative Commons Targeting epigenetics to treat cancer Transcription is a tightly regulated process, where chemical modifications initiate the duplication of genetic material. This epigenetic process is often dysregulated in cancer, but it can be targeted with small molecule inhibitors. Panagis Filippakopoulos 05 Oct 2015
174 Creative Commons A deep breath in Asthma and COPD (chronic obstructive pulmonary disease) are common conditions that affect the lives of many people. Mona Bafadhel 28 Jul 2015
175 Creative Commons Chemistry, epigenetics and drugs Alteration of gene expression is fundamental to many diseases. A better understanding of how epigenetic proteins affect diseases provides a starting point for therapy development and the discovery of new drug. Paul Brennan 28 Jul 2015
176 Creative Commons The genetics of metabolic diseases A missing step in a metabolic pathway leads to the build-up of toxic compounds, and the lack of materials essential for normal function. Wyatt Yue 28 Jul 2015
177 Creative Commons The economics of tropical diseases Economics and health are interlinked in many ways, as seen in the vicious cycle between poverty and ill health. Yoel Lubell 28 Jul 2015
178 Creative Commons Getting the dose right Too high a dose can result in toxicity and side-effects, too low a dose can cause the illness to come back and at worse develop resistance. Joel Tarning 28 Jul 2015
179 Creative Commons A deep breath in Asthma and COPD (chronic obstructive pulmonary disease) are common conditions that affect the lives of many people. Mona Bafadhel 28 Jul 2015
180 Creative Commons Chemistry, epigenetics and drugs Alteration of gene expression is fundamental to many diseases. A better understanding of how epigenetic proteins affect diseases provides a starting point for therapy development and the discovery of new drug. Paul Brennan 28 Jul 2015
181 Creative Commons The genetics of metabolic diseases A missing step in a metabolic pathway leads to the build-up of toxic compounds, and the lack of materials essential for normal function. Wyatt Yue 28 Jul 2015
182 Creative Commons The economics of tropical diseases Economics and health are interlinked in many ways, as seen in the vicious cycle between poverty and ill health. Yoel Lubell 28 Jul 2015
183 Creative Commons Getting the dose right Too high a dose can result in toxicity and side-effects, too low a dose can cause the illness to come back and at worse develop resistance. Joel Tarning 28 Jul 2015
184 Creative Commons Enteric fever Dr Christiane Dolecek speaks about the research on enteric fever she conducted in Vietman and Nepal Christiane Dolecek 20 May 2015
185 Creative Commons Enteric fever Dr Christiane Dolecek speaks about the research on enteric fever she conducted in Vietman and Nepal. Christiane Dolecek 20 May 2015
186 Creative Commons Oxford University Clinical Research Unit Vietnam (OUCRU) The Oxford University Clinical Research Unit (OUCRU) is a large-scale clinical and public health research unit based in Vietnam. Guy Thwaites 13 Apr 2015
187 Creative Commons Oxford University Clinical Research Unit Vietnam (OUCRU) The Oxford University Clinical Research Unit (OUCRU) is a large-scale clinical and public health research unit based in Vietnam. Guy Thwaites 13 Apr 2015
188 Creative Commons Emerging Infectious Diseases Professor Peter Horby is Senior Clinical Research Fellow. His research focusses on epidemic diseases such as Ebola and bird flu, and crosses the disciplines of basic science, medical science and public health. Peter Horby 11 Mar 2015
189 Emerging Infectious Diseases Professor Peter Horby is Senior Clinical Research Fellow. His research focusses on epidemic diseases such as Ebola and bird flu, and crosses the disciplines of basic science, medical science and public health. Peter Horby 11 Mar 2015
190 Creative Commons Human Cancer Genetics Dr Gareth Bond, Associate Member of the Ludwig Institute for Cancer Research, studies the influence of genetic variants on the origins, progression and treatment of human cancer. Gareth Bond 11 Mar 2015
191 Human Cancer Genetics Dr Gareth Bond, Associate Member of the Ludwig Institute for Cancer Research, studies the influence of genetic variants on the origins, progression and treatment of human cancer. Gareth Bond 11 Mar 2015
192 Creative Commons Personalised Medicine Dr Jenny Taylor is the Programme Director for the Genomic Medicine Theme, Wellcome Trust Centre for Human Genetics. Her research bridges the gap between genetics research and the use of its discoveries in diagnosis or treatment of medical conditions. Jenny Taylor 09 Feb 2015
193 Creative Commons Cancer predisposition and evolution Identifying genes that increase the risk of bowel or other cancers allows us to offer preventative measures, such as removing tumours at an early stage. A better understanding of how and why cancers grow also helps develop improved treatments. Ian Tomlinson 09 Feb 2015
194 Creative Commons Cancer Informatics Cancer research now generates huge amounts of data, and sophisticated computational tools are needed to answer biological questions. Making sense of this variability at molecular level will help us better tailor treatments to individual cancer patients. Benjamin Schuster-Böckler 09 Feb 2015
195 Biological imaging Video microscopy aims to improve target discovery and drug development and to do so generates large volumes of data. Jens Rittscher 09 Feb 2015
196 Pharmacogenomics Dr Sebastian Nijman develops new approaches to study signalling networks in cancer cells and uncover specific weaknesses, particularly in breast and lung cancer. This can be used to develop more effective drugs and to better guide treatment decisions. Sebastian Nijman 09 Feb 2015
197 Biological imaging Video microscopy aims to improve target discovery and drug development and to do so generates large volumes of data. Jens Rittscher 09 Feb 2015
198 Personalised Medicine Dr Jenny Taylor is the Programme Director for the Genomic Medicine Theme, Wellcome Trust Centre for Human Genetics. Her research bridges the gap between genetics research and the use of its discoveries in diagnosis or treatment of medical conditions. Jenny Taylor 09 Feb 2015
199 Cancer predisposition and evolution Identifying genes that increase the risk of bowel or other cancers allows us to offer preventative measures, such as removing tumours at an early stage. A better understanding of how and why cancers grow also helps develop improved treatments. Ian Tomlinson 09 Feb 2015
200 Cancer Informatics Cancer research now generates huge amounts of data, and sophisticated computational tools are needed to answer biological questions. Making sense of this variability at molecular level will help us better tailor treatments to individual cancer patients. Benjamin Schuster-Böckler 09 Feb 2015